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Excitatory cortical neurons form fine-scale functional networks
The specificity of cortical neuron connections creates columns of functionally similar neurons spanning from the pia to the white matter. Here we investigate whether there is an additional, finerExpand
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Fine-scale specificity of cortical networks depends on inhibitory cell type and connectivity
Excitatory cortical neurons form fine-scale networks of precisely interconnected neurons. Here we tested whether inhibitory cortical neurons in rat visual cortex might also be connected withExpand
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Persistent cortical plasticity by upregulation of chondroitin 6-sulfation
Cortical plasticity is most evident during a critical period in early life, but the mechanisms that restrict plasticity after the critical period are poorly understood. We found that a developmentalExpand
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Two Forms of Synaptic Plasticity with Distinct Dependence on Age, Experience, and NMDA Receptor Subtype in Rat Visual Cortex
In visual cortex, NMDA receptor (NMDAR) properties depend primarily on NR2A and NR2B subunits, and NR2 subunit composition changes with age and visual experience. We examined the roles of these NR2Expand
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Specialized Inhibitory Synaptic Actions Between Nearby Neocortical Pyramidal Neurons
We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal (excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currentsExpand
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Microglia contact induces synapse formation in developing somatosensory cortex
Microglia are the immune cells of the central nervous system that play important roles in brain pathologies. Microglia also help shape neuronal circuits during development, via phagocytosing weakExpand
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CTCF is required for neural development and stochastic expression of clustered Pcdh genes in neurons.
The CCCTC-binding factor (CTCF) is a key molecule for chromatin conformational changes that promote cellular diversity, but nothing is known about its role in neurons. Here, we produced mice with aExpand
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Targeted gene delivery to telencephalic inhibitory neurons by directional in utero electroporation
Telencephalic inhibitory neurons originate in the ganglionic eminences and migrate to the cerebral cortex following a tangential trajectory, before they differentiate and integrate within the localExpand
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Suppressive effects of receptive field surround on neuronal activity in the cat primary visual cortex
Effects of sinusoidal grating stimulus presented outside the classical receptive field (CRF) on neuronal responses were studied in the primary visual cortex of anaesthetized cats. Among 101 cellsExpand
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State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells
Cortical pyramidal neurons alter their responses to input signals depending on behavioral state. We investigated whether changes in somatic inhibition contribute to these alterations. In layer 5Expand
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