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Vitamin D deficiency may predict a poorer outcome of IgA nephropathy
TLDR
A 25( OH)D deficiency at baseline is significantly correlated with poorer clinical outcomes and more sever renal pathological features, and low levels of 25(OH)D at baseline were strongly associated with increased risk of renal progression in IgAN.
Imbalance of erythropoiesis and iron metabolism in patients with thalassemia
TLDR
Patients with thalassemia showed iron overload, reduced hepcidin levels, and a greater extent of ineffective erythropoiesis.
Identification of Key Genes and Pathways Associated with RUNX1 Mutations in Acute Myeloid Leukemia Using Bioinformatics Analysis.
TLDR
Identifying pivotal genes and pathways involved in RUNX1-mutated patients of with acute myeloid leukemia (AML) will help understand the molecular mechanisms underlying RunX1 mutations in AML and develop effective therapeutic strategies for RUNx1-mutation AML.
Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis
TLDR
GDF15, EPO concentrations, and GDF15 to sTfR and G DF15 to EPO ratios are able to determine the presence of EMH with considerable sensitivity and specificity, and are potential biomarkers for the early prediction of NTDT in patients who are at risk for EMH.
Iron overload correlates with serum liver fibrotic markers and liver dysfunction: Potential new methods to predict iron overload-related liver fibrosis in thalassemia patients
TLDR
Monitoring serum C IV, PIIINPC and HA is a potentially sensitive method to predict the risks for iron overload-related liver fibrosis in Chinese thalassemia patients.
Hb Southampton [β106(G8)Leu→Pro; HBB: c.320T>C] and Codons 41/42 (–TTCT; HBB: c.124_127delTTCT) in a Chinese Girl
TLDR
This mutation in a 2-year-old Chinese girl with a history of regular transfusions is the first time that this variant has been found in the Asian population and the main clinical presentation is hemolytic anemia.
Genome-scale integrated analysis to identify prospective molecular mechanisms and therapeutic targets in isocitrate dehydrogenase 2 R140Q-mutated acute myeloid leukemia
TLDR
Several co-expressing genes and potential molecular mechanisms that are instrumental in IDH2 R140Q-mutated adult de novo AML, along with 13 candidate targeted therapeutic drugs are identified.
Clinical presentation of the hemoglobin Youngstown variant in a Chinese family
TLDR
The three cases confirm the significant role of ineffective erythropoiesis in the pathophysiology of iron overload in Hb Youngstown carriers and suggest that the iron overload process in these carriers resembles that in patients with non-transfusion-dependent Yongrong Lai and Rongrong Liu.
A 15‐years follow‐up of deferasirox in beta‐thalassaemia major patients with iron overload
TLDR
The adverse event profile of inotuzumab ozogamicin in adult patients with relapsed or refractory acute lymphoblastic leukaemia and the results from the open-label, randomised, phase 3 INO-VATE study are published.
Iron overload status in patients with non-transfusion-dependent thalassemia in China
TLDR
This study provides a strong support for the novel findings that Chinese NTDT patients have a high prevalence of iron overload and should be performed as early as 5 years old.