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Determination of activities of human carbonic anhydrase II inhibitors from curcumin analogs
TLDR
These curcumin analogs have inhibitory potential againstCA-II; (3E, 5E)-3,5-bis[(2- hydroxyphenyl)methylidene]piperidin-4-one (a1) has the highest inhibitory activity and may be useful in the development of CA-II inhibitors for glaucoma treatment.
3,5-Bis(2-hydroxybenzylidene)piperidin-4-one
The title compound, 3,5-bis(2-hydroxybenzylidene)piperidin-4-one (3), was prepared via reaction of 2-hydroxybenzaldehyde (1) and 4-piperidone (2) under microwave irradiation in the presence of 10%
Crystal structures of 3,5-bis[(E)-3-hydroxybenzylidene]-1-methylpiperidin-4-one and 3,5-bis[(E)-2-chlorobenzylidene]-1-methylpiperidin-4-one
3,5-Bis[(E)-3-hydroxybenzylidene]-1-methylpiperidin-4-one and the 2-chlorobenzylidene derivative are monocarbonyl analogues of curcumin, and the conformations of the two compounds are very similar.
Synthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines
Three piperidone curcumin analogues (N-methyl-(3E,5E)-3,5-bis-(2-chlorobenzylidene)-4-piperidone (1), N-methyl-(3E,5E)-3,5-bis-(3-bromobenzylidene)-4-piperidone (2) and
Antioxidant and Antidiabetic Activities of Mempening (Lithocarpus bancanus) Leaves
TLDR
Hyperglycemia is found to increase the production of free radicals that are associated with long-term damage, dysfunction, and failure of various organs, especially eyes, kidneys, nerves, hearts, and blood vessels.
Synthesis , Structure-Activity Relationship , Docking and Molecular Dynamic Simulation of Curcumin Analogues Against HL-60 for Anticancer Agents ( Leukemia )
TLDR
Eight curcumin analogues were found to be active against HL-60 for anticancer and docking studies and MD showed that the presence of the hydroxyl group in the meta position can enhance the biological activity of compounds.
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