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Transient receptor potential vanilloid 1 (TRPV1) has been shown to alter its ionic selectivity profile in a time- and agonist-dependent manner. One hallmark of this dynamic process is an increased permeability to large cations such as N-methyl-D-glucamine (NMDG). In this study, we mutated residues throughout the TRPV1 pore domain to identify loci that(More)
We present a simulation study to increase the throughput at an Endoscopy center. The center has the capacity to process up to 80 patients a day. However, they were only processing about 50 patients/day, on average. We have built a simulation model to better understand the causes of this low throughput and to determine the worthiness of some proposed changes(More)
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