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Exosomes as drug delivery vehicles for Parkinson's disease therapy.
ExoCAT provided significant neuroprotective effects in in vitro and in vivo models of PD and has a potential to be a versatile strategy to treat inflammatory and neurodegenerative disorders.
Identification and Characterization of Sporulation-Dependent Promoters Upstream of the Enterotoxin Gene (cpe) of Clostridium perfringens
ABSTRACT Three promoter sites (P1, P2, and P3) responsible for the sporulation-associated synthesis of Clostridium perfringensenterotoxin, a common cause of food poisoning in humans and animals, were
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells.
A exosome-based system to carry formulation of PTX was developed and showed efficacy in the treatment of multi-drug resistant cancer cells and this novel system may be further developed to carry other chemotherapeutic agents in the future.
Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain.
It is demonstrated in vivo that naïve Mϕ exosomes, after intravenous (IV) administration, cross the blood-brain barrier and deliver a cargo protein, the brain derived neurotrophic factor (BDNF), to the brain.
Arabidopsis pollen tube integrity and sperm release are regulated by RALF-mediated signaling
It is proposed that RALF34 replaces RalF4 and RALf19 at the interface of pollen tube–female gametophyte contact, thereby deregulating BUPS-ANXUR signaling and in turn leading to pollen tube rupture and sperm release.
Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations.
The manufacture of targeted exosome-based formulations with superior structure and therapeutic indices for systemic administration of PTX-loaded exosomes with incorporated aminoethylanisamide-polyethylene glycol vector moiety to target the sigma receptor, which is overexpressed by lung cancer cells is reported.
Molecular pathogenesis of Klebsiella pneumoniae.
The state-of-the-art understanding of the molecular pathogenesis of K. pneumoniae is presented and a variety of virulence factors, especially capsule polysaccharide, lipopolysaccharides, fimbriae, outer membrane proteins and determinants for iron acquisition and nitrogen source utilization, for survival and immune evasion during infection are presented.
GDNF-Transfected Macrophages Produce Potent Neuroprotective Effects in Parkinson's Disease Mouse Model
Genetically-modified macrophages are evaluated for active targeted brain delivery of glial cell-line derived neurotropic factor (GDNF) to provide neuroprotective effects and serve as a new technology based on cell-mediated active delivery of therapeutic proteins that attenuate and reverse progression of PD.
Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury.
It was found that hemin-nitrite-H2O2 could induce liver homogenate protein nitration, lipid peroxidation and liver microsome protein oxidation and it also caused a decrease of HepG2 cells viability.
Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases
A novel class of vectors, genetically modified macrophages that carry reporter and therapeutic genes to neural cells are reported that serve as a highly efficient system for reproduction, packaging, and targeted gene and drug delivery to treat inflammatory and neurodegenerative disorders.