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Derrick neuFelD is an associate Professor of Information Systems at the richard Ivey School of Business, university of Western Ontario, london, Ontario. His research examines IT-facilitated distributed work arrangements, including consequences for employees (telecommuting), groups (virtual teamwork), and managers (remote leadership). Dr. Neufeld's research(More)
IgG monoclonal antibodies (mAbs) consist of two Fab fragments and one Fc fragment. The Fab fragments contain the variable regions and are responsible for drug specificity (via antigen binding); the Fc fragment contains constant regions and is responsible for effector functions (via interactions with Fcγ receptors) and extended serum half-life (via(More)
The neonatal Fc receptor (FcRn) is a key determinant of IgG homeostasis. It binds to the Fc domain of IgG in a strictly pH-dependent manner and protects IgG from lysosomal degradation. The impact of FcRn salvage pathway on IgG monoclonal antibody (mAb) pharmacokinetics (PK) has been well established. In this report, a set of mAbs with wild-type human Fc(More)
In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: In general, online buying behavior can be understood in two stages: the first stage is(More)
The objective of this study was to investigate the influence of exogenous 24-epibrassinolide (EBR) on the substances involved in antioxidation and osmoregulation responses of young grape plants under chilling stress. The grapevine leaves were sprayed with 0 (control), 0.05, 0.10 or 0.15 mg/L of 24-epibrassinolide and then exposed to 4 and 0 °C for 24 h,(More)
1 The effects of e-commerce institutional mechanisms on trust and online purchase have traditionally been understood in the initial online purchase context. This study extends this literature by exploring the role of e-commerce institutional mechanisms in the online repurchase context. In doing so, it responds to the emerging call for understanding the(More)
Productivity of remote workers is of critical concern to organizations and managers contemplating telecommuting arrangements. Here we suggest a general theoretical framework for understanding telecommuter productivity, and then report on a two-phased research study. In the first phase, semi-structured interviews with 32 telecommuters were conducted in one(More)