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Ubiquitination of eukaryotic proteins regulates a broad range of cellular processes, including regulation of T cell activation and tolerance. We have previously demonstrated that gene related to anergy in lymphocytes (GRAIL), a ring finger ubiquitin E3 ligase, is required for the induction of T cell anergy; however, the substrate(s) for GRAIL E3 ligase(More)
Ovarian follicle growth and oocyte maturation require communications between the oocyte and its surrounding somatic cells. Three-dimensional structures provide cell culture conditions that increase interactions between the cellular components when compared to 2-dimensional structures. In this study, alginate matrices were employed to maintain a(More)
The fields of gynecology, organ transplantation, tissue engineering and regenerative medicine are in the process of convergence, promising the development of novel treatments for infertility highlighted by the advent of the bioartificial uterus. The advances made with in vitro fertilization, immunology, and stem cell biology have reopened dialogue regarding(More)
Human pluripotent stem cells (hPSCs) have arisen as a source of cells for biomedical research due to their developmental potential. Stem cells possess the promise of providing clinicians with novel treatments for disease as well as allowing researchers to generate human-specific cellular metabolism models. Aging is a natural process of living organisms, yet(More)
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