Yuko Kojima

2Hideo Yagita
2Hisaya Akiba
2Ko Okumura
1Kazuyoshi Takeda
1Tomotaka Dohi
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Because tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in tumor cells and plays a critical role in tumor surveillance, its receptor is an attractive target for antibody-mediated tumor therapy. Here we report that a monoclonal antibody (mAb) against the mouse TRAIL receptor, DR5, exhibited potent antitumor(More)
BACKGROUND Several animal models have facilitated the evaluation and pathological understanding of atherosclerosis, but a definitive animal model of coronary atherosclerosis is not available. We therefore developed low density lipoprotein receptor knockout (LDLR-KO) pigs with hypercholesterolemia, a model which rapidly developed coronary atherosclerosis(More)
INTRODUCTION T cell immunoglobulin and mucin domain-2 (TIM-2) has been shown to regulate CD4 T cell activation. However, the role of TIM-2 in the autoimmune disease models has not been clarified yet. In this study, we investigated the effects of anti-TIM-2 monoclonal antibodies (mAbs) in collagen-induced arthritis (CIA) to determine whether TIM-2(More)
– Although image-based user authentication systems have gotten a lot of attention recently to reduce the burden of memorizing passwords, they can be vulnerable to shoulder-surfing attacks. To overcome this problem, shoulder-surfing-resistant image-based authentications with indirect image selection (indirect image-based authentication, or I-IBA) have been(More)
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