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Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling.
Linking bioactive compounds to their cellular targets is a central challenge in chemical biology. Here we report the mode of action of theonellamides, bicyclic peptides derived from marine sponges.… Expand
Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Identification of the cellular target of small molecules is a major challenge to developing biological tools and drug leads. Here we report a novel microarray-based system for identification of the… Expand
Targeting cholesterol in a liquid-disordered environment by theonellamides modulates cell membrane order and cell shape.
Roles of lipids in the cell membrane are poorly understood. This is partially due to the lack of methodologies, for example, tool chemicals that bind to specific membrane lipids and modulate membrane… Expand
Visualization of Sterol-Rich Membrane Domains with Fluorescently-Labeled Theonellamides
Cholesterol plays important roles in biological membranes. The cellular location where cholesterol molecules work is prerequisite information for understanding their dynamic action. Bioimaging probes… Expand