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A neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which produces pathological changes similar to human idiopathic Parkinson's disease in animals, was injected in mice for biochemical and pharmacological studies. The dopamine concentration showed a marked decrease (-75%) in the striatum 1-2 weeks after the injection of MPTP (30 mg/kg i.p.(More)
We studied cerebral metabolism in 82 patients with nonfamilial parkinsonism, including Parkinson's disease (PD; n = 23), progressive supranuclear palsy (PSP; n = 12), corticobasal degeneration (CBD; n = 19), multiple systemic atrophy (MSA; n = 18) and vascular parkinsonism (VP; n = 10) by using proton magnetic resonance spectroscopy ((1)H-MRS), which(More)
To elucidate how the size of the expanded CAG repeat of the gene for dentatorubral pallidoluysian atrophy (DRPLA) and other factors affect the atrophy of the brainstem and cerebellum, and the appearance of high-intensity signals on T2-weighted MRI of the cerebral white matter of patients with DRPLA, we quantitatively analyzed the MRI findings of 26 patients(More)
We investigated the localizing and lateralizing value of principal seizure manifestations in temporal lobe epilepsies (signal symptoms, oroalimentary automatisms, somatomotor manifestations, unilateral dystonic posturing, ictal speech, motionless stare) of 223 complex partial seizures in 50 patients. All the patients had invasive long-term monitoring with(More)
The effects of tricyclic antidepressants (imipramine, desipramine and amitriptyline) on the NMDA receptor-mediated synaptic responses and the induction of long-term potentiation were investigated in the CA1 region and the dentate gyrus of rat hippocampal slices. Both in the CA1 region and in the dentate gyrus, all three antidepressants (3 x 10(-5)M) did not(More)
Possible involvement of nitric oxide (NO) in the induction of long-term potentiation (LTP) in the amygdala was investigated using rat brain slice preparations in vitro. The induction of LTP in the medial amygdala was blocked by NO synthase inhibitors, NG-nitro-L-arginine and NG-nitro-L-arginine methyl ester, and an NO scavenger hemoglobin. On the other(More)
We studied whether N-acetylaspartate (NAA), a neuronal marker, is reduced in the brain of 14 patients with clinically definite amyotrophic lateral sclerosis (ALS) and whether NAA levels in the motor area and frontal lobe correlate with the clinical features, including frontal lobe function. We also studied 14 normal controls were evaluated. We obtained peak(More)
The purpose of this study was to evaluate the effects of the auditory stimulus presentation rate on signal response during fMRI with a minimal effect of scanner acoustic noise. Six subjects received auditory stimulus with a pure tone (1000 Hz, 30 ms duration) at presentation rates of 0.5, 2, 5, 10 and 20 Hz. Echo planar images were obtained with a long TR(More)
The effects of beta-adrenoceptor activation on short-term potentiation in the medial and lateral amygdala were investigated using rat brain slice preparations in vitro. Application of tetanic stimulation (100 pulses at 100 Hz) induced only short-term potentiation under normal recording conditions. In the medial amygdala, when the same tetanic stimulation(More)