Yukio Kuroiwa

Learn More
CYP2C8 plays important roles in metabolizing therapeutic drugs and endogenous compounds. Although genetic polymorphisms of CYP2C8 were reported, there is little information on CYP2C8 polymorphisms in the Japanese population. In the present study, we screened for previously described polymorphisms in the coding region of this gene using polymerase chain(More)
Nicotine is widely consumed throughout the world, and exerts a number of physiological effects. After nicotine is absorbed through the lungs by cigarette smoking, it undergoes extensive metabolism in humans. Nicotine is mainly metabolized to cotinine by cytochrome P450 (CYP) 2A6. CYP2A6 can metabolize some pharmaceutical agents such as halothane, valproic(More)
The maximum plasma radioactivity levels of tritium (3H)-labeled cephaeline, (24.3, 28.7 and 40.6 ng eq./mL) were reached at 2.00-3.33 hours following oral dosing of ipecac syrup. The maximum plasma radioactivity levels of3H-emetine (2.71, 6.47 and 9.62 ng eq./mL) were reached at 1.08–2.33 hours following ipecac syrup administration. The Cmax values(More)
Treatment of rats with phénobarbital (PB) caused an increase in microsomal biphenyl 4-hydroxylase activity and urinary glucaric acid excretion. Hepatic microsomal biphenyl 4-hydroxylase activity was correlative with urinary glucaric excretion in PB-treated rats. Hepatic microsomal biphenyl 2-hydroxylase activity was not correlated with urinary glucaric(More)
This research was designed to determine whether the convulsion-eliciting action of tranylcypromine (TCP) during barbital (B) withdrawal was specific to physical dependence on B, and to compare the findings with the action of pentetrazol (PTZ). Challenge with 15–20 mg/kg IP TCP at 48 h of B withdrawal resulted in the elicitation of clonictonic convulsion(More)
The effect of adrenalectomy (Adx), SKF 525-A, phenobarbital (PB), and diethyl maleate (DEM) on the acute toxicity of fenitrothion was investigated in male rats by assessing the degree of plasma cholinesterase activity. PB, 60 mg/kg/day for 3 days, exerted no protective effect on the toxicity of fenitrothion (100 mg/kg, p.o.) given 24 h after the last(More)
We have recently demonstrated that bufalin is a new potent inducer of the differentiation of human myeloid leukemia cells. The present work was carried out to examine further the effect of bufalin on the growth and characteristics of human leukemia-derived cell lines U937, Mil. and HL60. At concentrations of 5-10 IIM,bufalin decreased the growth of Mil(More)
  • 1