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Transplantation of Clonal Neural Precursor Cells Derived from Adult Human Brain Establishes Functional Peripheral Myelin in the Rat Spinal Cord
- Yukinori Akiyama, O. Honmou, T. Kato, T. Uede, J. Kocsis
- Biology, Medicine
- Experimental Neurology
- 31 January 2001
We examined the myelin repair potential of transplanted neural precursor cells derived from the adult human brain from tissue removed during surgery. Sections of removed brain indicated that… Expand
Chloroquine potentiates temozolomide cytotoxicity by inhibiting mitochondrial autophagy in glioma cells
Mitochondrial autophagy eliminates damaged mitochondria and decreases reactive oxygen species (ROS). The autophagy inhibitor chloroquine (CQ) potentiates temozolomide (TMZ) cytotoxicity in glioma… Expand
Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cord
- S. Oka, O. Honmou, Yukinori Akiyama, M. Sasaki, J. Kocsis
- Biology, Medicine
- Brain Research
- 24 December 2004
The objective of this study was to establish if neural precursor cells could safely be developed from biopsy of the subventricular zone (SVZ) in the non-human primate (marmoset), and to determine… Expand
Integration of engrafted Schwann cells into injured peripheral nerve: Axonal association and nodal formation on regenerated axons
- C. Radtke, Yukinori Akiyama, K. Lankford, P. Vogt, J. Kocsis
- Medicine, Biology
- Neuroscience Letters
- 21 October 2005
Transplantation of myelin-forming cells can remyelinate axons, but little is known of the sodium channel organization of axons myelinated by donor cells. Sciatic nerve axons of female wild type mice… Expand
Therapeutic temperature modulation in severe or moderate traumatic brain injury: a propensity score analysis of data from the Nationwide Japan Neurotrauma Data Bank.
OBJECTIVE In patients with severe traumatic brain injury (TBI), a randomized controlled trial revealed that outcomes did not significantly improve after therapeutic hypothermia (TH) or normothermia… Expand
The influence of depth of anesthesia on motor evoked potential response during awake craniotomy.
OBJECTIVE Motor evoked potentials (MEPs) are a critical indicator for monitoring motor function during neurological surgery. In this study, the influence of depth of anesthesia on MEP response was… Expand
ACTC1 as an invasion and prognosis marker in glioma.
OBJECTIVE Glioma is a major class of brain tumors, and glioblastoma (GBM) is the most aggressive and malignant type. The nature of tumor invasion makes surgical removal difficult, which results in… Expand
Pathophysiological consideration of medullary streaks on FLAIR imaging in pediatric moyamoya disease.
OBJECTIVE Medullary streaks detected on fluid-attenuated inversion recovery (FLAIR) imaging have been considered to be reflected ischemic regions in pediatric moyamoya disease. The purpose of this… Expand
Intraoperative Mapping and Monitoring for Rootlets of the Lower Cranial Nerves Related to Vocal Cord Movement.
BACKGROUND Damage to the motor division of the lower cranial nerves that run into the jugular foramen leads to hoarseness, dysphagia, and the risk of aspiration pneumonia; therefore, its functional… Expand