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Experimental brain tumors were produced in cats by xenotransplantation of the rat glioma clone F98 into the white matter of the left hemisphere. One to 4 weeks after implantation, local adenosine triphosphate (ATP), glucose, lactate, and tissue pH were measured via imaging techniques in cryostat sections passing through the center of the tumor and(More)
Experimental gliomas (F98) were inoculated in cat brain for the systematic study of their in vivo T2 relaxation time behavior. With a CPMG multi-echo imaging sequence, a train of 16 echoes was evaluated to obtain the transverse relaxation time and the magnetization M(0) at time t = 0. The magnetization decay curves were analyzed for biexponentiality. All(More)
Multiexponential evaluation of in vivo multi-echo T2 measurements at 4.7T in cat brain with implanted tumour led to monoexponential results in all tissues. T2 of normal brain tissue, tumour and oedema was 67 ms, 10-100 ms and 90-180 ms, respectively. In the ventricles biexponential solutions were observed with T2 values and relative contributions of these(More)
The regional distribution of ATP, glucose, lactate and tissue pH was studied by bioluminescence and fluoroscopic imaging of intact cryostat sections of implantation tumors of cat. In tumors, marked heterogeneity of metabolites and pH was present: in solid parts ATP was similar to normal brain but glucose tended to decrease with an increase in lactate and pH(More)
For the validation of volume-selective 1H and 31P NMR spectroscopy of the brain methods are required that allow high resolution quantitative mapping of tissue pH and metabolites on intact brain slices. The following techniques are proposed for this purpose. Tissue pH is imaged on cryostat sections of in situ frozen brains, using umbelliferone as a(More)
The effect of increasing static magnetic field strength up to 4.7 Tesla on the electrical function of the cat brain was studied by EEG frequency analysis and recording of somatosensory evoked potentials. While the latencies of the peaks P6 and P10 of the somatosensory evoked potentials were stable during the time course of the experiment, EEG intensity, EEG(More)
Livers from wild pufferfish, Takifugu rubripes, can be described as having a smooth frontal side and an upper-region that is attached to the hepatic portal vein. Based on this description, the liver can be divided into 10 parts (L1-5 and R1-5), and in this work, the lethal potency of each part was determined by mouse bioassay. Among the raw livers from 58(More)
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