Yukiko Yoshimoto

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Cynaropicrin is a guaianolide sesquiterpene lactone with a 5-7-5 tricyclic skeleton, four exo-olefins, and two hydroxyl groups. Recently, it was found that the compound is a potent in vitro and in vivo inhibitor of the protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis (HAT; sleeping sickness). In this Letter, chemical(More)
Ca2+ channel activities were recorded in the limb bud of embryonic day 4 chick with Ca2+ sensitive fluorescence (Fura-2) measurements and patch clamp techniques. Rises in intracellular Ca2+ concentrations were evoked by depolarization with the application of 100 mM K+ and this Ca2+ response was abolished by removing extracellular Ca2+. The Ca2+ response was(More)
Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis. To explore their structure-antitrypanosomal activity relationships, a set of 34 natural and semi-synthetic STLs and amino-STLs was tested in vitro against T.(More)
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