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Molecular complex consisting of two typical external medicines: intermolecular interaction between indomethacin and lidocaine.
TLDR
The changes of IR spectra in the C=O stretching region showed that each intact hydrogen bond network was collapsed in the IDM-LDC system and strong interaction between IDM and LDC formed after their kneading.
Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator.
TLDR
A novel inhibitor of GRP78 expression, designated as prunustatin A, was isolated from Streptomyces violaceoniger 4521-SVS3 by analyzing chemically degraded components obtained from the derivative of prunUSTatin A.
Prunustatin A, a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger
TLDR
Punustatin A inhibited the expression of GRP78 induced by 2-deoxyglucose in human fibrosarcoma HT1080 cells accompanied by global cell death without showing cytotoxicity under normal nutrient condition.
Characterization of multicomponent crystal formed between indomethacin and lidocaine
TLDR
Crystalline complex was formed between indomethacin (IDM) and lidocaine (LDC) at molar ratio 2:1 from ethanol solution and revealed that a primary interactive force between IDM and LDC molecule was coulomb energy.
Crystal Structure of a 2:1 Complex of Indomethacin and Lidocaine
Crystals of a 2:1 complex, (Cl9H16ClNO4)2·C14H22N2O, between indomethacin and lidocaine were grown by slow evaporation from an ethanol solution. Two different indomethacin (I and II) molecules showed
Quality Testing of Steroidal Ointment Mixed with White Petrolatum: Rheological Properties and Stability Testing
We investigated the uniformity of content, rheological properties and chemical stability for prescription of Kindavate® ointment diluted with white petrolatum. When the ointment was levigated with
[Adhesion loss of syrups in a metering glass which consists of a low surface free energy material].
TLDR
Measurements of syrup contact angles suggested that in metering devices made of PP and PMP, which have low surface free energies, a decrease in the spreading wetting of syrups was a factor in reducing the rate of adhesion loss.
Method of Administering Powdered Medicines to Infants: Investigation of Optimal Water Amounts for Achieving a Paste State in Powdered Medicines
TLDR
The results suggest that the optimal water amount for powdered medicines of various weights can be estimated from standard volumes of water by proportion and may be useful for the administration of mixed powdered medicines to infants.
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