Yukihisa Suzuki

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PURPOSE Positron emission tomography (PET), the blood flow response in the primary visual cortex (V1) to two visual stimuli, low temporal frequency (6 Hz) to activate the parvocellular system, and high temporal frequency (25 Hz) to activate the magnocellular system were used to investigate pathophysiologic mechanism of amblyopia. METHODS Five women and(More)
Essential blepharospasm (EB) is classified as a form of focal dystonia characterized by involuntary spasms of the musculature of the upper face. The basic neurological process causing EB is not known. The purpose of this study was to investigate cerebral glucose metabolism in patients with EB whose symptoms were suppressed by an injection of botulinum-A(More)
PURPOSE We evaluated optic radiation (OR) damage in patients with glaucoma by using fractional anisotropy (FA) of diffusion-tensor magnetic resonance imaging. METHODS We studied 29 patients with glaucoma and 19 healthy controls. Regions of interest were placed over the bilateral anterior and posterior ORs on the FA maps, and the FA value of each region(More)
PURPOSE To evaluate alteration of the optic radiation (OR) in patients with retinitis pigmentosa (RP) using fractional anisotropy (FA) measured by diffusion tensor MRI. METHODS We performed MRI and evaluated alteration of the ORs in 17 patients with RP and 27 healthy controls. Regions of interest were placed over the bilateral anterior and posterior areas(More)
OBJECTIVES The purpose of this study was to investigate whether dopamine D(2) receptor binding was altered in the striatum of essential blepharospasm patients. METHODS Striatal dopamine D(2) receptor binding was measured with positron emission tomography and [(11)C]raclopride. We studied eight drug-naive patients with bilateral blepharospasm and eight(More)
To localize regional alterations in cerebral glucose metabolism in essential blepharospasm (EB) patients with photophobia. We have studied 22 EB patients by performing positron emission tomography and [(18)F]-fluorodeoxyglucose analysis. The patients were classified into two subgroups, namely, EB with photophobia (P group) and EB without photophobia (NP(More)
PURPOSE Although activation of the lateral geniculate nucleus (LGN) has been shown by functional magnetic resonance imaging, a quantitative evaluation of the activity has not been reported by positron emission tomography (PET). The purpose of this study was to quantify the degree of activation of the LGN and other vision-related structures by visual stimuli(More)
In this study, we investigated gray matter density in essential blepharospasm (EB) patients, focusing on the duration of disease and severity of symptoms. We studied 32 patients (10 males and 22 females; age, 55.0 ± 6.5years) with EB and 48 controls (15 males and 33 females; age, 54.4 ± 10.3years) by using 3D T1-weighted magnetic resonance imaging and(More)
Dystonia is an involuntary movement disorder dominated by sustained muscle contractions that frequently cause twisting, repetitive movements, and postural changes. The purpose of this study was to determine the mechanism causing dystonia. We therefore employed a rat model of dystonia, which was induced by injecting (-)-bicuculine methiodide (BM), a(More)
BACKGROUND To demonstrate the efficacy of positron emission tomography (PET) for examining multiple sclerosis (MS) patients with hemianopia. CASE A 20-year-old man visited us with a complaint of left homonymous hemianopia and headache. OBSERVATIONS The patient's visual acuity was 1.2 (n.c.) OD and 0.9 (1.0) OS. Magnetic resonance imaging (MRI) showed a(More)