Yukihiro Imanishi

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BACKGROUND/AIMS We studied the effect of Inchin-ko-to (TJ-135), a herb medicine that has been clinically used for liver cirrhosis in Japan, on liver fibrosis in a rat model and on the function of stellate cells. METHODS Rat liver fibrosis was generated by thioacetamide (TAA) administration. DNA synthesis was assessed by 5-bromo-2'-deoxyuridine(More)
BACKGROUND/AIMS We tested the pharmacological action of sulfur-containing amino acids on the development of liver fibrosis in rats and on the function of cultured stellate cells. METHODS Liver fibrosis was induced in rats by thioacetamide administration or by ligating the common bile duct. DNA synthesis of cultured stellate cells was evaluated by BrdU(More)
Introduction Herbal medicine has been recognized as one of useful treatments for chronic liver diseases. Inchinko-to (TJ135) consists of Artemisia Capillaris Spike, Gardenia Fruit and Rhubarb Rhizome. Artemisia Capillaris Spike and Gardenia Fruit promote bile secretion [1,2]. Rhubarb Rhizome is used for constipation. Rhubarb Rhizome contains anthraquinone(More)
We attempted to measure the area and volume of visceral fat using magnetic resonance (MR) imaging to avoid radiation exposure. We used water suppression-spectral attenuation with inversion recovery (WS-SPAIR) as prepulses and conducted T(1) high-resolution isotropic volume examination (THRIVE). Image processing software can be used to estimate the area and(More)
One diagnostic criterion for metabolic syndrome is obesity from the accumulation of visceral fat; others include abdominal circumference and area of visceral fat as measured by computed tomography (CT) at the umbilical level. We evaluated visceral fat using frequency-selective excitation magnetic resonance (MR) imaging SPAIR (spectral attenuation with(More)
Introduction Regulation of hepatic stellate cell activation is currently one of the focuses of clinical investigation in order to establish a useful therapeutic strategy for liver fibrosis. Because oxidative stress caused at the inflammatory site and reactive oxygen species derived from damaged hepatocytes has been thought to pull the trigger for the cell(More)
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