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Novel Wide-Range Quantitative Nested Real-Time PCR Assay for Mycobacterium tuberculosis DNA: Development and Methodology
TLDR
Due to the development of the NM-plasmid as the new internal control, significantly improved quantitative accuracy and a wider detection range were realized with the WR-QNRT-PCR assay.
Protuboxepins A and B and protubonines A and B from the marine-derived fungus Aspergillus sp. SF-5044.
Two new oxepin-containing (1 and 2) and two diketopiperazine-type alkaloids (3 and 4) have been isolated from an EtOAc extract of the marine-derived fungus Aspergillus sp. SF-5044. The structures of
Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp.
TLDR
Azaspirene inhibits the endothelial migration induced by vascular endothelial growth factor in Neosartorya sp.
Identification of Cytochrome P450s Required for Fumitremorgin Biosynthesis in Aspergillus fumigatus
TLDR
Missing links in the fumitremorgin biosynthetic pathway have been elucidated as crucial processes for the inhibitory activity of fum it Remorgin C against breast cancer resistance protein (BCRP).
Aflaquinolones A-G: secondary metabolites from marine and fungicolous isolates of Aspergillus spp.
Seven new compounds (aflaquinolones A-G; 1-7) containing dihydroquinolin-2-one and terpenoid units have been isolated from two different fungal sources. Two of these metabolites (1 and 2) were
Isolation and synthesis of a new bioactive ellagic acid derivative from Combretum yunnanensis.
TLDR
Compound 1 showed weak inhibitory activity against the growth of various tumor cells and inhibited HIV-1 protease and the absolute configuration of 1 was determined.
Novel Wide-Range Quantitative Nested Real-Time PCR Assay for Mycobacterium tuberculosis DNA: Clinical Application for Diagnosis of Tuberculous Meningitis
TLDR
The WR-QNRT-PCR assay is considered to be a useful and advanced assay technique for assessing the clinical treatment course of TBM.
Development of pyrrole-imidazole polyamide for specific regulation of human aurora kinase-A and -B gene expression.
TLDR
Two specific PIPs (PIP-A and PIP-B) targeting AURKA and AURKB promoter regions were designed and synthesized, and their biological effects were investigated by several in vitro assays.
Verrucarin A sensitizes TRAIL-induced apoptosis via the upregulation of DR5 in an eIF2α/CHOP-dependent manner.
TLDR
It is concluded that VA triggers TRAIL-induced apoptosis by eIF2α/CHOP-dependent DR5 induction via ROS generation and generation of reactive oxygen species (ROS) is an effector molecular in sensitization of VA-induced ER stress.
Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells.
TLDR
The mechanism by which protuboxepin A induces cancer cell growth inhibition, round-up morphology, M phase arrest, and an increase in the subG(1) population in tumor cells in a dose dependent manner are elucidated.
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