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Long-term in vivo carcinogenicity tests of potassium bromate (KBrO3), sodium hypochlorite (NaClO), and sodium chlorite (NaClO2) have been conducted in Japan from 1977 to 1985. In these investigations, groups of approximately 50 male and 50 female F344 rats or B6C3F1 mice were given solutions of the compounds as their drinking water ad libitum at two dose(More)
The development and aging of four brain midline structures--the pituitary gland, pons, cerebellar vermis, and corpus callosum--were studied. The dimensions and area of these structures were measured by means of midsagittal magnetic resonance imaging. The study group consisted of 94 patients newborn to 15 years old and 49 patients and seven volunteers 16-60(More)
OBJECTIVE To investigate the relationship between cerebral cortical function and white matter myelination in the visual pathway in the evaluation of normal brain development. METHODS The authors performed quantitative analysis of white matter myelination detected with conventional T1-weighted spin echo (SE) MRI and brain functional MRI (fMRI) using(More)
Activity-dependent synaptic plasticity has been thought to be a cellular basis of memory and learning. The late phase of long-term potentiation (L-LTP), distinct from the early phase, lasts for up to 6 h and requires de novo synthesis of mRNA and protein. Many LTP-related genes are enhanced in the hippocampus during pentyrenetetrazol (PTZ)- and kainate(More)
The carcinogenic activities of sodium chlorite in B6C3F1 mice were examined. Sodium chlorite was given at concentrations of 0 (control), 0.025% (low dose), or 0.05% (high dose) in the drinking water of 150 female and 150 male mice for 80 weeks, after which time the animals were returned to distilled water without sodium chlorite. All mice were sacrificed 85(More)
BACKGROUND Most Japanese pediatric neurologists attempt other treatments before using adrenocorticotropic hormone (ACTH) therapy for West syndrome (WS), and even then, they use only a low-dose synthetic ACTH to avoid serious adverse effects. In this multi-institutional study, the authors analyzed the initial effects, adverse effects, and long-term outcome(More)
An implantable device for measurement of cerebrospinal fluid (CSF) flow in a ventriculoperitoneal shunt tube has been developed. The unit is energized by an extracorporeal high-frequency generator (200 KHz), and electrolysis creates bubbles in the shunt tube. Velocity of bubble flow is detected by a pair of ultrasonic Doppler probes placed a certain(More)
SUMMARY We retrospectively analysed to demonstrate the selection of the treatment modality and its efficacy in our department. Subjects of the present study comprised patients in whom coil embolization was abandoned due to such reasons as broad neck, whom coil embolization was performed for residual aneurysm following incomplete clipping or recurrent(More)
Three neonatal patients with superior sagittal sinus thrombosis are reported. The neurologic signs were bulging of the anterior fontanel and clonic hemi-convulsions. Neonatal polycythemia was believed to be an etiologic factor in two patients. Computed tomography revealed massive edema with slit-like ventricles in two patients. Increased density of the(More)
Normal development and maturation in pre- and postnatal periods were studied using MR imaging. For this purpose, we performed MR imaging at a postmenstrual age of 37-44 weeks in both low-risk preterm and fullterm infants and assessed the myelination pattern and the dimension of the pituitary gland, corpus callosum, pons and cerebellar vermis. There were no(More)