Yuki Nakajima

Hidetaka Uramoto8
Hiroyasu Kinoshita8
Hirohiko Akiyama4
Mitsuro Fukuhara2
8Hidetaka Uramoto
8Hiroyasu Kinoshita
4Hirohiko Akiyama
2Mitsuro Fukuhara
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ATM and ATR protein kinases play a crucial role in cellular DNA damage responses. The inhibition of ATM and ATR can lead to the abolition of the function of cell cycle checkpoints. In this regard, it is expected that checkpoint inhibitors can serve as sensitizing agents for anti-cancer chemo/radiotherapy. Although several ATM inhibitors have been reported,(More)
BACKGROUND Although the concept of induction therapy followed by surgical resection for locally advanced non-small cell lung cancer (LA-NSCLC) has found general acceptance, the appropriate indications and the strategy for this treatment are still controversial. METHODS From 2000 through 2008, 36 patients received concurrent chemoradiotherapy followed by(More)
Recent new drugs, such as bevacizumab (Bev), also result in a remarkable response. However, the safety of major lung resection after the use of Bev remains controversial. Is it really dangerous to perform major lung resection after the use of Bev for a lung tumor? In this report, we describe two patients who underwent surgery safely without fragile(More)
  • Naoto Tatewaki, Tetsuya Konishi, Yuki Nakajima, Miyako Nishida, Masafumi Saito, Takahiro Eitsuka +4 others
  • 2016
Ataxia telangiectasia mutated (ATM) kinase plays a crucial role as a master controller in the cellular DNA damage response. Inhibition of ATM leads to inhibition of the checkpoint signaling pathway. Hence, addition of checkpoint inhibitors to anticancer therapies may be an effective targeting strategy. A recent study reported that Wip1, a protein(More)
INTRODUCTION Surgery for locally advanced lung cancer is carried out following chemoradiotherapy. However, there are no reports clarifying what the effects on the subsequent prognosis are when surgery is carried out in cases with radiation pneumonitis. In this paper, we report on 2 cases of non-small cell lung cancer with Grade 2 radiation pneumonitis after(More)
INTRODUCTION When considering treatment for pulmonary cancer complicated by interstitial pneumonia, the greatest problem is acute exacerbation. We report two cases of pulmonary cancer complicated by interstitial pneumonia in which multiple intrapulmonary lymph nodes were noted. CASE PRESENTATIONS Cases 1 and 2 were 76- and 62-year-old males, respectively.(More)
INTRODUCTION Bronchoplasty is performed for both curability and preservation of the pulmonary function. CASE PRESENTATION We herein report the findings of a 65-year old female patient who was admitted to our hospital to undergo surgical treatment for lung cancer. We successfully performed left upper lobe double sleeve lobectomy and reconstructed the site(More)
Selecting the proper treatment strategy for locally advanced lung cancer, such as T4 tumors, is difficult. Therefore, obtaining an accurate diagnosis of T4 tumors is required. It can be difficult to determine whether the tumor invades adjacent structures. We describe the case of a patient easily diagnosed to be without aortic invasion using cine magnetic(More)
BACKGROUND To make a preoperative determination of the degree of adhesion of the lymph node (LN) to the pulmonary artery (PA) in patients with lung cancer. METHODS We investigated clinical parameters, including sex, age, smoking, stage, histology and surgical procedure, and performed an image analysis using CT scanning. RESULTS The data for sex, age,(More)