Yuki Kawaguchi

Publications14
h-index4
Citations64
Highly Influential Citations4
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Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocket.
TLDR
The heme pocket of CYP3A4 is very flexible and is able to interact with various types of substrate and be bound by two selected ligand accessible regions. Expand
Photoinduced oligomerization of Arabidopsis thaliana phototropin 2 LOV1.
TLDR
The reactions of the Arabidopsis phototropin 2 LOV1 (phot2LOV1) domain were revealed by the transient grating (TG) method and it was suggested that the hinge region undergoes a conformational change during the photoreaction. Expand
When is the helix conformation restored after the reverse reaction of phototropin?
Following the disruption of the covalent bond between the cysteine and flavin of Phot1LOV2-linker, the unfolded conformation of the linker folds with a time constant of 13 ms, which is considerably… Expand
Cytolytic Activity and Molecular Feature of Cardiotoxin and Cardiotoxin-like Basic Protein: The Electrostatic Potential Field Is an Important Factor for Cell Lytic Activity.
TLDR
The distribution of ESP fields may affect the cytolytic activity of the CT family and stereo-hydrophobicities and molecular torsions of CT and CLBP were similar. Expand
Molecular profiles of cholesterol-dependent cytolysin family-derived 11mer regions.
TLDR
Traditional CDCs, ILY, PLO, and VLY consisted of four domains, and domain 0 existed on the N-terminal side in Sm-hPAF in addition to thesefour domains, which influenced the species specificity and membrane recognition of each cytolysin. Expand
An Antitumor 2-Hydroxyarylidene-4-cyclopentene-1,3-Dione as a Protein Tyrosine Kinase Inhibitor: Interaction Between TX-1123 Derivatives and Src Kinase.
TLDR
Tyrphostin AG17 analogs, such as TX-1123, with Src kinase (Src-K), differed from each other, while their SRC-K inhibitory activities were affected by their fit in the S RCK molecule. Expand
Profiles of ILY, VLY and Sm-hPAF interaction with human CD59.
TLDR
A hydrogen bond was observed between ILY and hCD59, and a stronger interaction was formed by flexible adjustment between them, suggesting that a new member of the bacterially -derived cytolysin family was examined. Expand
TRIM32-Cytoplasmic-Body Formation Is an ATP-Consuming Process Stimulated by HSP70 in Cells
TLDR
It is found that HSP70, a central QC component, is a primary binding factor of overexpressed TRIM32, and it is suggested that CB inclusion formation is actively controlled by cellular QC and requires ATP, similar to protein folding and degradation reactions. Expand
Structure-associated Functional Control of TX-1877 Series by Glyco-conjugation
TLDR
The conformations and hydrophobicities of chemical compounds may be controlled by adding monosaccharide- and tetra-O-acetyl-conjugated sugars to TX-1877. Expand
Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs.
TLDR
The COX-inhibitory activities of TX-1123 derivatives with the 2-hydroxyarylidene-4-cyclopentene-1,3-dione structure were examined, and the binding profiles of TX -1123 to COXs were analyzed using docking simulations. Expand
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