Yukari Nagai

Learn More
It has been suggested that IL-1 produces cartilage matrix degradation by metalloproteinases such as collagenase, and that such degradation is regulated by metalloproteinase inhibitors (TIMP). Therefore, the balance between collagenase and TIMP is an important factor for tissue destruction in inflammatory joints. In the present study the effects of cytokines(More)
This study investigated the design process in order to clarify the characteristics of the essence of the creative design process vis-à-vis the interpretation process, by carrying out design experiments. The authors analyzed the characteristics of the creative design process by comparing it with the linguistic interpretation process, from the viewpoints of(More)
The objective of this paper was to study the effects of interleukin 4 (IL-4) and interleukin 6 (IL-6) on cartilage matrix degradation, the production of chondroitin-4-sulphate (C4S) and chondroitin-6-sulphate (C6S), metalloproteinase (stromelysin 1 = MMP-3) and metalloproteinase inhibitor (TIMP-1) production. Cartilage matrix degradation was assayed the(More)
Previous investigators have attributed the fall of brain intracellular pH (pHi) produced by ischemia to accumulation of lactic acid. The goal of the present experiments was to examine the hypothesis that the acidosis produced by cerebral ischemia is due to accumulation of lactic acid. The present experiments inhibited lactic acid production by lowering(More)
This paper proposes a model of meta-reflection and in-depth analysis of the knowledge creation process (KCP). The authors focus on observation of the KCP in research on creative design. The new method of meta-reflection is applied both to reflection on ‘research about design creativity’ and object of research—‘design creativity’. One result of the applied(More)
In this paper, we describe two experiments for examining how designers think with drawings in order to generate visual images of the design object. In the first experiment, we assigned to subjects the task of designing a chair, which evokes a 'sad image'. An assumption of our work, based on previous experiments, is that an abstract keyword is more difficult(More)
In this study, we propose a method for the design of a creative and emotional motion. Our work is based on the hypothesis that a creative motion that is beyond the ordinary human imagination can produce emotional impressions that resonate with deep feeling. The proposed method involves computer implementation of motion blending, movement analogous to(More)
In this study, we develop a method for designing an emotional and creative motion that resonates with deep feelings. This study is based on the hypothesis that motion that is beyond ordinary human imagination can produce emotional impressions that resonate with deep feelings. The proposed method involves an analogy with natural objects, the blending of(More)