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The endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several endothelium-derived relaxing factors, such as prostacyclin, nitric oxide (NO), and the previously unidentified endothelium-derived hyperpolarizing factor (EDHF). In this study, we examined our hypothesis that hydrogen peroxide (H(2)O(2)) derived(More)
Purpose We evaluated the role of tumor necrosis factor alpha (TNFa) in rat ovulation and granulosa cell death of ovarian follicles during the periovulatory stage. Methods Immature rats primed with pregnant mare serum gonadotropin were injected intraperitoneally with human chorionic gonadotropin (hCG), and TNFa was injected into the bursa 48 h later. The(More)
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