Yukako Nakayama

Learn More
Light- and electron-microscopic studies and immunohistochemical procedures were carried out on blood eosinophils and left ventricular endomyocardial biopsies from a 68-year-old man with an eosinophilia of 8.2 × 109/l and congestive cardiac failure due to eosinophilic endomyocardial disease. Some blood eosinophils were vacuolated and degranulated, and(More)
Nitric oxide (NO) has been known to play various functional and pathological roles as an intracellular or intercellular messenger in the heart. In this study, we investigated whether NO produced during ischemia was involved in the coordination of ATP supply and demand, and also in protection from cell death using cultured cardiac myocytes. Unexpectedly, the(More)
Openings of the central canal in the filum terminale internum of the rabbit, guinea pig, and rat have been studied by light and electron microscopy. There were two openings in the rabbit, two or three in the guinea pig, and one in the rat. They opened dorsally and were of two types; one type was without a pial covering, the other with a pial covering. In(More)
Isolated and cultured neonatal cardiac myocytes contract spontaneously and cyclically. The intracellular concentration of free Ca(2+) also changes rhythmically in association with the rhythmic contraction of myocytes (Ca(2+) oscillation). Both the contraction and Ca(2+) oscillatory rhythms are synchronized among myocytes, and intercellular communication via(More)
Intraperitoneal gelatin sponge implants were used in guinea-pigs to examine the effect of D-penicillamine on the delayed hypersensitivity reaction in vivo. When it was administered daily in a dose of 200 mg/kg for 14 days before sensitisation or for 14 or 30 days before challenge, D-penicillamine increased the number of exudate cells during the onset of the(More)
The lymphotoxin system (LT) regulates interactions between lymphocytes and stromal cells to maintain lymphoid microenvironmental homeostasis. Soluble LT beta-receptor-Ig (LTβRIg) blocks lymphocyte LTα1β2-stromal cell LTβR signaling. In a murine cardiac allograft model, LTbRIg treatment reversed the tolerance induced by anti-CD40L antibody leading to graft(More)
Isolated and cultured neonatal cardiac myocytes contract spontaneously and cyclically. The contraction rhythms of two isolated cardiac myocytes, each of which beats at different frequencies at first, become synchronized after the establishment of mutual contacts, suggesting that mutual entrainment occurs due to electrical and/or mechanical interactions(More)