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- Makiya Nishikawa, Kohei Ogawa, +8 authors Yoshinobu Takakura
- Journal of controlled release : official journal…
- 2014
DNA nanotechnology-based nanosystems and macrosystems have attracted much attention in the biomedical research field. The nature of DNA endows these systems with biodegradable, biocompatible, and… (More)
- Yuka Umeki, Kohta Mohri, +5 authors Makiya Nishikawa
- 2015
Previous studies indicate that immunostimulatory DNA-based injectable hydrogels harboring unmethylated cytosine-phosphate-guanine (CpG) dinucleotides meet the requirements of an effective antigen… (More)
- Yu Nishida, Shozo Ohtsuki, +8 authors Makiya Nishikawa
- Nanomedicine : nanotechnology, biology, and…
- 2016
Immunoinhibitory oligodeoxynucleotides (INH-ODNs) are promising inhibitors of Toll-like receptor 9 (TLR9) activation. To efficiently deliver INH-ODNs to TLR9-positive cells, we designed a… (More)
- Tomoya Yata, Yuki Takahashi, +8 authors Makiya Nishikawa
- Biomaterials
- 2017
Success of tumor photothermal immunotherapy requires a system that induces heat stress in cancer cells and enhances strong anti-tumor immune responses. Here, we designed a composite-type… (More)
- Shota Uno, Makiya Nishikawa, +6 authors Yoshinobu Takakura
- Nanomedicine : nanotechnology, biology, and…
- 2014
UNLABELLED
Investigation of mouse macrophage-like RAW264.7 cells showed that the immunostimulatory activity of CpG DNA is increased by formation of polypod-like structured DNA (polypodna), an… (More)
- Yumiko Ishii-Mizuno, Yuka Umeki, +5 authors Makiya Nishikawa
- Journal of controlled release : official journal…
- 2015
To develop an immunotherapeutic vaccine for treatment of allergic rhinitis, we developed a controlled release formulation of Cryj1, a major Japanese cedar pollen allergen, with immunostimulatory… (More)
- Yumiko Ishii-Mizuno, Yuka Umeki, +4 authors Makiya Nishikawa
- International journal of pharmaceutics
- 2017
Immunostimulatory DNA hydrogel (sDNA hydrogel) containing unmethylated cytosine-phosphate-guanine (CpG) sequences has been demonstrated to be a useful antigen delivery system, which can effectively… (More)
- Yuka Umeki, Masaaki Saito, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa
- Advanced healthcare materials
- 2017
Our previous study indicates that cationization of an antigen is effective for sustained release of both immunostimulatory DNA containing unmethylated cytosine-phosphate-guanine (CpG) dinucleotides,… (More)
- Yumiko Ishii-Mizuno, Yuka Umeki, +5 authors Makiya Nishikawa
- 2017
- Yuka Umeki, Masaaki Saito, +5 authors Makiya Nishikawa
- Journal of controlled release : official journal…
- 2018
Our previous study demonstrated that the incorporation of a tumor antigen into a self-assembling DNA hydrogel, comprised of a DNA containing un-methylated cytosine-phosphate-guanine (CpG)… (More)