Yuka Tosaki

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OBJECTIVES Fexofenadine contains a chiral carbon in its chemical structure and is orally administered as a racemic mixture. This study evaluated the selective uptake of fexofenadine enantiomers by Caco-2 cells as a model of intestinal epithelial cells. METHODS R(+)-fexofenadine or S(-)-fexofenadine was applied to Caco-2 cells, followed by incubation.(More)
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