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Chemokines and cytokines in neuroinflammation leading to neuropathic pain.
TLDR
Investigation concerning the functions of the chemokine-cytokine network-mediated regulation of neuroinflammation may lead to novel therapeutic strategies against intractable neuropathic pain. Expand
Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury.
TLDR
It is suggested that pioglitazone alleviates neuropathic pain through attenuation of proinflammatory cytokine upregulation by PPARgamma stimulation. Expand
The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice.
TLDR
The results suggest that the invading peripheral macrophage-derived interleukin (IL)-6 plays a critical role in vincristine-induced mechanical allodynia. Expand
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4‐phenylbutyrate, a chemical chaperone
TLDR
The results suggest that this rotenone mouse model may be useful for understanding the mechanism of DA neurodegeneration in PD, and that 4‐PBA has a neuroprotective effect in the treatment of PD. Expand
Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation
TLDR
A novel critical molecule MIP‐1&agr; derived from macrophages and Schwann cells is proposed that appears to play a crucial role in the development of neuropathic pain induced by PSL. Expand
Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice
TLDR
The results suggest that VCR treatments elicited the activation of glial cells in spinal cord, and up-regulated TNF-alpha in these cells may play an important role in VCR-induced mechanical allodynia. Expand
Epigenetic Augmentation of the Macrophage Inflammatory Protein 2/C-X-C Chemokine Receptor Type 2 Axis through Histone H3 Acetylation in Injured Peripheral Nerves Elicits Neuropathic Pain
TLDR
Hyperacetylation of histone H3 on the promoter region of MIP-2 and CXCR2 located in the injured peripheral nerve elicits chronic neuroinflammation through neutrophil accumulation, leading to neuropathic pain. Expand
Leptin enhances CC-chemokine ligand expression in cultured murine macrophage.
TLDR
Leptin enhances CCLs expression in cultured murine macrophage, through activation of a JAK2-STAT3 pathway, and a new paradigm of leptin-mediated chemokine expression may lead to the clarification of complex immune systems in future. Expand
HMGB1 as a potential therapeutic target for neuropathic pain.
TLDR
The characteristics of HMGB1 as a pro-inflammatory mediator are overviewed and the promise ofHMGB1 is shown as a therapeutic target for neuropathic pain is shown. Expand
Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury
TLDR
Both this suppressive effect on mechanical response and delayed facilitation of pH response was reversed by PPADS and suramin, demonstrating that these effects are mediated by P2 receptors. Expand
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