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Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid‐β peptides via p75NTR/PLAIDD
It is shown that PLAIDD and Gi proteins, heterotrimeric G proteins, are involved in the alternative Aβ‐induced neurotoxicity mediated by p75NTR, and that HN, ADNF, IGF‐I, or bFGF inhibits both pathways.
Differential Localization of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 and CD47 and Its Molecular Mechanisms in Cultured Hippocampal Neurons
Polarized localization of membrane proteins to axons or dendrites is important for a variety of neuronal functions, including neurite outgrowth and synaptogenesis during neural development. Src…
Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1
- T. Miki, Yasunao Kamikawa, S. Kurono, Yuka Kaneko, J. Katahira, Y. Yoneda
- BiologyBMC Molecular Biology
- 16 November 2011
These results indicate that the recruitment of Stau2 alone or in combination with Upf1 differentially affects the fate of mRNAs, and suggest that Stau 2-mediated fate determination could be executed in a cell type-specific manner.
Resistance to Experimental Autoimmune Encephalomyelitis and Impaired T Cell Priming by Dendritic Cells in Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Mutant Mice1
Results show that SHPS-1 on DCs is essential for priming of naive T cells and the development of EAE, and is thus a potential therapeutic target in inflammatory disorders of the CNS and other autoimmune diseases.
Characterization and localization of side population cells in the lens
- M. Oka, C. Toyoda, Yuka Kaneko, Y. Nakazawa, E. Aizu-Yokota, M. Takehana
- Biology, MedicineMolecular vision
- 29 May 2010
The results suggest that SP cells in the lens contain a high proportion of stem cells, and these stem cells are localized around the germinative zone.
Regulation by Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 of α-Galactosylceramide-Induced Antimetastatic Activity and Th1 and Th2 Responses of NKT Cells1
Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 (SHPS-1), a transmembrane protein abundantly expressed on DCs, appears to be essential for α-GalCer-induced antimetastatic activity and Th1 and Th2 responses of NKT cells.
Resistance to collagen-induced arthritis in SHPS-1 mutant mice.
Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47–SHPS-1 system
The results suggest that trans-endocytosis of CD47 is responsible for removal of the CD47–SHPS-1 complex from the cell surface and hence regulates the function of theCD47–shps-1 system, at least in neurons and glial cells.
Regulation of multiple functions of SHPS-1, a transmembrane glycoprotein, by its cytoplasmic region.
Identification of potential breast cancer markers in nipple discharge by protein profile analysis using two‐dimensional nano‐liquid chromatography/nanoelectrospray ionization‐mass spectrometry
ND has been proposed as a source of secreted proteomes that reflect early pathological changes in the ductal‐lobular epithelial microenvironment, and could thus provide breast‐specific cancer biomarkers that could be accessed noninvasively as a new clinical diagnostic technique.