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Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid‐β peptides via p75NTR/PLAIDD
One of the most important pathological features of Alzheimer's disease (AD) is extracellular senile plaques, whose major component is amyloid‐β peptides (Aβ). Aβ binds to the extracellular domain ofExpand
Resistance to Experimental Autoimmune Encephalomyelitis and Impaired T Cell Priming by Dendritic Cells in Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Mutant Mice1
Src homology 2 domain-containing protein tyrosine phosphatase (SHP) substrate-1 (SHPS-1) is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 through itsExpand
Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1
BackgroundStaufen2 (Stau2), a double-stranded RNA-binding protein, is a component of neuronal RNA granules, which are dendritic mRNA transport machines. Although Stau2 is thought to be involved inExpand
Differential Localization of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 and CD47 and Its Molecular Mechanisms in Cultured Hippocampal Neurons
Polarized localization of membrane proteins to axons or dendrites is important for a variety of neuronal functions, including neurite outgrowth and synaptogenesis during neural development. SrcExpand
Characterization and localization of side population cells in the lens
Purpose Side population (SP) cells were isolated and the possibility whether lens epithelial cells contain stem cells was investigated. Methods Mouse lens epithelial cells were stained by HoechstExpand
Regulation by Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 of α-Galactosylceramide-Induced Antimetastatic Activity and Th1 and Th2 Responses of NKT Cells1
Interaction of α-galactosylceramide (α-GalCer) presented by CD1d on dendritic cells (DCs) with the invariant TCR of NKT cells activates NKT cells. We have now investigated the role of Src homology 2Expand
Resistance to collagen-induced arthritis in SHPS-1 mutant mice.
SHPS-1 is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is abundantly expressed on dendritic cells and macrophages. Here weExpand
Regulation of multiple functions of SHPS-1, a transmembrane glycoprotein, by its cytoplasmic region.
SHPS-1 is a receptor-type transmembrane glycoprotein, which contains four tyrosine residues in its cytoplasmic region, and the phosphorylation of these tyrosine residues serves the binding sites forExpand
Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47–SHPS-1 system
CD47 and SHPS-1 are transmembrane proteins that interact with each other through their extracellular regions and constitute a bidirectional cell-cell communication system (the CD47–SHPS-1 system). WeExpand
Identification of potential breast cancer markers in nipple discharge by protein profile analysis using two‐dimensional nano‐liquid chromatography/nanoelectrospray ionization‐mass spectrometry
This research aimed to establish a diagnostic technique for breast cancer using nipple discharge (ND), with the objective of preventive diagnosis. ND has been proposed as a source of secretedExpand
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