Yuka Hoshiya

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A new pseudo coloring technique for large scale one-dimensional datasets is proposed. For visualization of a large scale dataset, user interaction is indispensable for selecting focus areas in the dataset. However, excessive switching of the visualized image makes it difficult for the user to recognize overview/ detail and detail/ detail relationships. The(More)
A pharmacodynamic analysis of cis-diamminedichloroplatinum(II) (DDP) was conducted using two human gastric cancer xenografts, SC-1-NU and MKN-45, and one human breast cancer xenograft, MX-1, grown serially in BALB/c nu/nu mice. DDP was administered intraperitoneally (i.p.) at a total dose of 5, 10, or 20 mg/kg in a schedule of q7d x 3 or (qd x 5) x 3. DDP(More)
Human tumors are generally methionine (MET)-dependent in that their growth is inhibited by MET-depletion down to levels that will still allow normal cell growth. The differential effect of methionine depletion on tumor and normal cells has suggested that methionine depletion may be able to modulate many and possibly all classes of cancer drugs. In this(More)
A pharmacokinetic analysis of cis-diamminedichloroplatinum (II) (DDP) was conducted comparing low-dose daily bolus infusions, and high-dose drip infusions. Eight patients with gastric cancer were treated with low-dose daily bolus infusions of DDP to a total daily dose of 75 mg/m2 bid for 5 days. Four patients with esophageal cancer and one patient with(More)
BACKGROUND Paclitaxel (BMS-181339: Taxol) is a promising agent against previously treated breast cancer. The antitumor activity of paclitaxel was evaluated using five human breast carcinoma xenografts in nude mice. METHODS Paclitaxel at 20 mg/kg dissolved in 0.2 ml ethanol/cremophor EL solution was administered intraperitoneally daily for 5 days. (More)
There are few agents with activity against metastatic breast cancer. We therefore exploited the elevated methionine dependence of tumors to develop a selective and effective therapy against metastatic breast and other cancers. Methionine starvation leads to depleted methionine levels in cells, modifies methylation reactions, lowers glutathione levels and(More)
A 71-year-old male with advanced gastric carcinoma with paraaortic lymph node metastases underwent distal gastrectomy. Cisplatin (CDDP) 50 mg/body was administered intravenously (i.v.) on day 1 followed by the administration of 5-fluorouracil 500 mg/body/day i.v. on day 2 through day 7. After two courses of this regimen, further enlargement of paraaortic(More)
A pharmacodynamic study of cisplatin (DDP) was conducted using the gastric cancer cell lines MKN-45 and MKN-74 in vitro. Ten thousand tumor cells were incubated with 0.4-500 micrograms/ml DDP for 1-25 h, followed by recovery culture for a further 48 h. At the end of incubation, cell viability was detected by the MTT end-point, and the inhibition rate was(More)
A 70-year-old male was admitted for obstructive jaundice. He was diagnosed as an unresectable advanced cancer of the gall bladder that was stage IV associated with direct extension of the liver (Hinf3) and the bile duct (Binf3), and with enlargement of paraaortic lymph node (N4(+)) by image analyses. Intraarterial infusion therapy with cisplatin (CDDP, 50(More)