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Stomata are natural openings through which many pathogenic bacteria enter plants. Successful bacterial pathogens have evolved various virulence factors to promote stomatal opening. Here, we show that the Pseudomonas syringae type III effector protein AvrB induces stomatal opening and enhances bacterial virulence in a manner dependent on RPM1-INTERACTING4(More)
Epigenetic mechanisms play a key role in gastrointestinal cancer (GIC) development and progression, and most studies have been focused on aberrant DNA methylation and histone modifying enzymes. However, the histone H3-H4 chaperone ASF1A is an important factor regulating chromatin assembling and gene transcription, while it is currently unclear whether ASF1A(More)
In this paper, a new capillary electrophoresis (CE) separation and detection method was developed for the chiral separation of the four major Cinchona alkaloids (quinine/quinidine and cinchonine/cinchonidine) using hydroxypropyl-β-cyclodextrin (HP-β-CD) and chiral ionic liquid ([TBA][L-ASP]) as selectors. Separation parameters such as buffer concentrations,(More)
Some feedback pathways are critical in the process of tumor development or malignant progression. However the mechanisms through which these pathways are epigenetically regulated have not been fully elucidated. Here, we demonstrated that the histone demethylase RBP2 was crucial for TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit that was implicated(More)
An approach for the synthesis of fluorescent organic nanoparticles (FONs) with a quantum yield of about 14% has been developed using polyethylenimine and sucrose. The FONs were prepared under mild reaction condition. The obtained FONs showed high water dispersibility, intense fluorescence, excitation-dependent emission feature, excellent nanoparticle(More)
Small and medium-sized enterprises have made great contribution to the prosperity of market economy and the stability of social order in China, but they often suffer from the financing difficulties. Supply chain finance model is a new angle of view to solve the financing difficulties of small and medium-sized enterprises. Firstly, this paper defines the(More)
Gene therapy has promising applications in ovarian cancer therapy. Blocking the function of the survivin protein could lead to the growth inhibition of cancer cells. Herein, we used degradable heparin-polyethyleneimine (HPEI) nanoparticles to deliver a dominant-negative human survivin T34A (hs-T34A) gene to treat ovarian cancer. HPEI nanoparticles were(More)
Nanoparticles have great promise for gene delivery. However, the transfection efficiency of nanoparticle-based gene delivery systems is always unsatisfied to meet the requirement of effective gene therapy. Herein, we used low dosage paclitaxel to enhance a nanoscaled gene delivery system that was self-assembled from DOTAP and MPEG-PLA(DPP), creating a(More)
Stomata are natural openings through which many pathogenic bacteria enter plants. Successful bacterial pathogens have evolved various virulence factors to promote stomatal opening. Here, we show that the Pseudomonas syringae type III effector protein AvrB induces stomatal opening and enhances bacterial virulence in a manner dependent on RPM1INTERACTING4(More)
This work reports that Cu(II) complexes with l-proline were used as chiral additives for the enantioseparations and determination of three underivatized amino acids by ligand-exchange micellar electrokinetic chromatography (LE-MEKC). Sodium dodecylsulfate (SDS) was shown to be necessary for simultaneous separation of the enantiomeric amino acids. Separation(More)