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- Shih-Min A. Huang, Yuji Mishina, +33 authors F. Z. Cong
- Nature
- 2009
The stability of the Wnt pathway transcription factor β-catenin is tightly regulated by the multi-subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many cancers,… (More)
- Jiwang Zhang, Chao Niu, +11 authors Linheng Li
- Nature
- 2003
Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-renewal and of forming all types of blood cells (multi-potential). However, the HSC ‘niche’—the in vivo… (More)
- Xi C. He, Jiwang Zhang, +8 authors Linheng Li
- Nature Genetics
- 2004
In humans, mutations in BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden disease, respectively. The development of polyposis is a… (More)
- Hidemasa Oh, Steven B Bradfute, +9 authors Michael H. Schneider
- Proceedings of the National Academy of Sciences…
- 2003
Potential repair by cell grafting or mobilizing endogenous cells holds particular attraction in heart disease, where the meager capacity for cardiomyocyte proliferation likely contributes to the… (More)
- Paul B Yu, Donna Y. Deng, +12 authors Kenneth D. Bloch
- Nature Medicine
- 2008
Fibrodysplasia ossificans progressiva (FOP) is a congenital disorder of progressive and widespread postnatal ossification of soft tissues and is without known effective treatments. Affected… (More)
- Yuji Mishina, Aya Suzuki, Naoto Ueno, Richard R. Behringer
- Genes & development
- 1995
Bone morphogenetic proteins (BMPs) are secreted proteins that interact with cell-surface receptors and are believed to play a variety of important roles during vertebrate embryogenesis. Bmpr, also… (More)
- Soazik P. Jamin, Nelson Alexander Arango, Yuji Mishina, Mark C. Hanks, Richard R. Behringer
- Nature Genetics
- 2002
Elimination of the developing female reproductive tract in male fetuses is an essential step in mammalian sexual differentiation. In males, the fetal testis produces the transforming growth factor β… (More)
- Thomas Andl, Kyung Ok Ahn, +12 authors Sarah E. Millar
- Development
- 2004
Bone morphogenetic protein (BMP) signaling is thought to perform multiple functions in the regulation of skin appendage morphogenesis and the postnatal growth of hair follicles. However, definitive… (More)
- Deborah A Greer Card, Pratibha B. Hebbar, +4 authors Trevor K Archer
- Molecular and cellular biology
- 2008
Oct4 and Sox2 are transcription factors required for pluripotency during early embryogenesis and for the maintenance of embryonic stem cell (ESC) identity. Functional mechanisms contributing to… (More)
Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2.
- Eric Thomas Domyan, Elisabetta Ferretti, Kurt Throckmorton, Yuji Mishina, Silvia K Nicolis, Xin Sun
- Development
- 2011
The mammalian foregut gives rise to the dorsally located esophagus and stomach and the ventrally located trachea and lung. Proper patterning and morphogenesis of the common foregut tube and its… (More)