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Localization of SMAP2 to the TGN and its function in the regulation of TGN protein transport.
SMAP2 is an Arf GTPase-activating protein that is located and functions on early endosome membranes. In the present study, the trans-Golgi network (TGN) was verified as an additional site of SMAP2Expand
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Disruption of Microtubule Network Rescues Aberrant Actin Comets in Dynamin2-Depleted Cells
A large GTPase dynamin, which is required for endocytic vesicle formation, regulates the actin cytoskeleton through its interaction with cortactin. Dynamin2 mutants impair the formation of actinExpand
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Receptor Sorting within Endosomal Trafficking Pathway Is Facilitated by Dynamic Actin Filaments
Early endosomes (EEs) are known to be a sorting station for internalized molecules destined for degradation, recycling, or other intracellular organelles. Segregation is an essential step in suchExpand
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PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes
PtdIns4KIIα has been implicated in the regulation of endosomal traffic, but the role of its enzymatic activity and the site of its action have not been elucidated. Depletion of PtdIns4KIIαExpand
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Receptor sorting and actin dynamics at early endosomes
The sorting machinery in early endosomes is crucial for intracellular homeostasis and signal transduction and its disruption leads to the development of various diseases. In spite of itsExpand
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The Arf GTPase-activating protein SMAP1 promotes transferrin receptor endocytosis and interacts with SMAP2.
Arf GTPase-activating proteins (Arf GAP) play important roles in the formation of the membrane vesicles that traffic between subcellular membranous organelles. The small Arf GTPase-activating proteinExpand
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Phosphatidic acid induces EHD3-containing membrane tubulation and is required for receptor recycling.
EHD3 is localized on the tubular structures of early endosomes, and it regulates their trafficking pathway. However, the regulatory mechanism of EHD3-containing tubular structures remains poorlyExpand
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Image-Based Profiling Can Discriminate the Effects of Inhibitors on Signaling Pathways under Differential Ligand Stimulation
A major advantage of image-based phenotypic profiling of compounds is that numerous image features can be sampled and quantitatively evaluated in an unbiased way. However, since this assay is aExpand
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The relation between AC permeability and dislocation density and grain size in pure iron
Magnetic properties of an iron-based steel derived from its major hysteresis loop are very sensitive to its microstruc- tures and have been, therefore, used for nondestructive evaluation (NDE) ofExpand
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PRACTICE AND EVALUATION OF THE EXPERIENCE-BASED ENVIRONMENTAL EDUCATION PROGRAM FOR UNDERGRADUATE STUDENTS AT EXPO'70 COMMEMORATIVE PARK IN SUITA, OSAKA, JAPAN
本稿では, 万博公園での大学生3年生向けの体験型環境教育プログラムを対象として, プログラム参加者 (被験者) への教育効果の把握手法の開発とその手法の適用を試みた. 教育効果は演習目的に掲げる環境学習, 社会貢献, 自己実現の3つを基本指標として, 各指標の下位項目を定め, 計40項目からなるアンケート調査票によって計測した.Expand