Yuichiro Morishita

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STUDY DESIGN This was a radiographic reliability study of a novel grading system for cervical intervertebral disc degeneration. OBJECTIVES This study aimed to develop and test the reliability of a reproducible grading system for cervical intervertebral disc degeneration on the basis of the routine magnetic resonance imaging (MRI). SUMMARY OF BACKGROUND(More)
A congenitally narrow cervical spinal canal has been established as an important risk factor for the development of cervical spondylotic myelopathy. However, few reports have described the mechanism underlying this risk. In this study, we investigate the relationship between cervical spinal canal narrowing and pathological changes in the cervical spine(More)
Laminoplasty for thoracic and lumbar spine surgery enables surgeons to preserve the posterior arch of the spine while preventing invasion of hematoma and scar tissue, postoperative instability, subluxation, and kyphotic deformities. The authors have developed a new surgical technique: namely, transverse placement laminoplasty (TPL) using titanium(More)
STUDY DESIGN Rat spinal fusion model. OBJECTIVE This study aimed to compare the efficacy of lentiviral gene therapy, and adenoviral gene therapy in inducing spinal fusion in an immune competent rat spinal fusion model. SUMMARY OF BACKGROUND DATA Recombinant bone morphogenetic proteins (BMPs) have also been used for spinal fusion successfully in clinical(More)
Bone morphogenetic binding peptide (BBP) is an 18.5 kDa fragment of a bone matrix protein peptide. A rat femoral defect model was used to test the effect of BBP combined with recombinant human bone morphogenetic protein-7 (rhBMP-7) to induced bone healing. Two doses of BBP (500 and 1000 µg) were tested with two doses of rhBMP-7 (2 and 5 µg), and the results(More)
STUDY DESIGN Rat spinal fusion model. OBJECTIVE To compare the efficacy of human adipose tissue-derived mesenchymal stem cells (HATDMSCs) and human bone marrow-derived mesenchymal stem cells (HBMDMSCs) transduced with an adenovirus containing the cDNA for bone morphogenetic proteins (BMP)-2 for inducing spinal fusion in an athymic rat model. SUMMARY OF(More)
STUDY DESIGN Retrospective analysis using kinetic magnetic resonance images (MRIs). OBJECTIVE To investigate the relationship of changes in the sagittal alignment of the cervical spine on the kinematics of the functional motion unit and disc degeneration. SUMMARY OF BACKGROUND DATA Normal lordotic alignment is one of the most important factors(More)
STUDY DESIGN A retrospective, consecutive case series. OBJECTIVE To determine the risk factors that have a statistically significant association with the need of tracheostomy in patients with cervical spinal cord injury (CSCI) at the acute stage. SUMMARY OF BACKGROUND DATA Respiratory complications remain a major cause of further morbidity and mortality(More)
STUDY DESIGN The kinematic study of human lumbar spinal movements. OBJECTIVE To investigate how disc degeneration and the degeneration of facet joint, ligaments, and paraspinal muscles are associated with lumbar segmental mobility. SUMMARY OF BACKGROUND DATA Previous studies revealed relationship between spinal motion and osteoarthritic changes of facet(More)
BACKGROUND CONTEXT Recombinant bone morphogenetic proteins (rhBMPs) have been used successfully in clinical trials. However, large doses of rhBMPs were required to induce adequate bone repair. Collagen sponges (CSs) have failed to allow a more sustained release of rhBMPs. Ongoing research aims to design carriers that allow a more controlled and sustained(More)