Yuichiro Miyaki

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Polyamines (spermine and spermidine) play many important roles in cellular function and are supplied from the intestinal lumen. We have shown that continuous high polyamine intake inhibits age-associated pathologies in mice. The mechanism by which polyamines elicit these effects was examined. Twenty-four week old Jc1:ICR male mice were fed one of three(More)
Patients with long-standing ulcerative colitis (UC) have higher risk of developing colorectal cancer. Albeit the causes remain to be understood, epigenetic alterations have been suggested to play a role in the long-term cancer risk of these patients. In this work, we developed a novel microarray platform based on methylation-sensitive amplified fragment(More)
The Pleckstrin and Sec7 domain-containing (PSD) gene, which regulates skeletal rearrangements, has been found to be more frequently methylated both in ulcerative colitis (UC)-associated colorectal cancer tissues (5 of 7; 71.4%) and matched normal epithelia (4 of 7; 57.1%) compared to non-neoplastic UC epithelia (6 of 22; 27.3%) and sporadic colorectal(More)
Recent work led to recognize sessile serrated adenomas (SSA) as precursor to many of the sporadic colorectal cancers with microsatellite instability (MSI). However, comprehensive analyses of DNA methylation in SSA and MSI cancer have not been conducted. With an array-based methylation sensitive amplified fragment length polymorphism (MS-AFLP) method we(More)
Drug resistance remains a major obstacle to successful cancer treatment. Genome-wide comprehensive analysis identified a novel gene, glucocorticoid-induced protein-coding gene (DEXI), which was frequently methylated in colorectal (CRC; 36 of 73 patients; 49%) and gastric (28 of 89 patients; 31%) cancer patients.(More)
Helicobacter pylori (HP) infection is widely recognized as a risk factor for gastric cancer, but only a minority of infected individuals develop gastric cancer. The aim of this study was to determine whether DNA demethylation in non-cancerous gastric mucosa (NGM) significantly enhances susceptibility to gastric cancer.(More)
Wandering spleen is a rare clinical entity, and its chronic torsion of the vascular pedicle result in splenic vein occlusion leading to gastric varices. Here, we present a case of wandering spleen complicating gastric varices in a 40-year-old female. Three-dimensional CT (3D-CT) clearly showed the disruption of the splenic vein at the origin of the vascular(More)
Yuta Muto (yutamuto@jichi.ac.jp) Takafumi Maeda (takafumim@hotmail.com) Koichi Suzuki (ksuzbnhm@omiya.jichi.ac.jp) Takaharu Kato (tkato@jichi.ac.jp) Fumiaki Watanabe (fwatanabe210@yahoo.co.jp) Hidenori Kamiyama (kamiyama@omiya.jichi.ac.jp) Masaaki Saito (msaito@jichi.ac.jp) Kei Koizumi (koizumi@hmedc.or.jp) Yuichiro Miyaki (miyaki@hama-med.ac.jp) Fumio(More)
We previously reported that the Pleckstrin and Sec7 domain-containing (PSD) gene is preferentially methylated in patients with ulcerative colitis (UC) who developed colorectal cancer (CRC), and is implicated in UC-associated carcinogenesis through its inhibition of apoptosis. This study aimed to determine the potential(More)
Objectives: This study aimed to evaluate whether before or after of hernia defect closure is thought to be best for the decision about the mesh size in intraperitoneal onlay mesh Repair (IPOM-Plus). Material and Methods: The subjects were 11 patients receiving IPOM-Plus between June 2014 and Feburary 2016, who were made a follow-up CT after surgery. Hernia(More)