Learn More
Synaptic plasticity, neuronal activity-dependent sustained alteration of the efficacy of synaptic transmission, underlies learning and memory. Activation of positive-feedback signaling pathways by an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) has been implicated in synaptic plasticity. However, the mechanism that determines the [Ca(2+)](i)(More)
  • Richard Kent, Cameron R Bass, William Woods, Christopher Sherwood, N J Madeley, Robert Salzar +1 other
  • 2003
Thoracic deformation under an applied load is an established indicator of injury risk, but the force required to achieve an injurious level of deformation currently is not understood adequately. This article evaluates how two potentially important factors, loading condition and muscle tensing, affect the structural response of the dynamically loaded thorax.(More)
Novel organo-Eu(III) luminophores, Eu(hfa)x(CPO)y and Eu(hfa)x(TCPO)y (hfa: hexafluoroacetylacetonate, CPO: 4-carboxyphenyl diphenyl phosphine oxide, TCPO: 4,4',4″-tricarboxyphenyl phosphine oxide), were synthesized by the complexation of Eu(III) ions with hfa moieties and CPO or TCPO ligands. The thermal and luminescent stabilities of the luminophores are(More)
Cellular ribozymes exhibit catalytic activity in media containing large numbers of anionic compounds and macromolecules. In this study, the RNA cleavage activity of the hammerhead ribozyme induced by Mg2+ was investigated using the solutions containing background nucleic acids, small phosphate and carboxylic acid compounds, and neutral polymers. Analysis of(More)
Nucleic acids are useful for biomedical targeting and sensing applications in which the molecular environment is different from that of a dilute aqueous solution. In this study, the influence of various types of mixed solutions of water and water-soluble organic compounds on RNA was investigated by measuring the catalytic activity of the hammerhead ribozyme(More)
OBJECTIVES The objective of this study is to examine the effectiveness of the active head restraint system in reducing neck injury risk of car occupants in low-speed rear impacts. METHODS A human body FE model "THUMS" was used to simulate head and neck kinematics of the occupant and to evaluate loading to the neck. Joint capsule strain was calculated to(More)
Posterior translation of the tibia with respect to the femur can stretch the posterior cruciate ligament (PCL). Fifteen millimeters of relative displacement between the femur and tibia is known as the Injury Assessment Reference Value (IARV) for the PCL injury. Since the anterior protuberance of the tibial plateau can be the first site of contact when the(More)
  • 1