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PURPOSE The objectives of this study were to characterize the differential potency of two major VEGF isoforms, VEGF(120) and VEGF(164), for inducing leukocyte stasis (leukostasis) within the retinal vasculature and blood-retinal barrier (BRB) breakdown and to determine whether endogenous VEGF(164) mediates retinal leukostasis and BRB breakdown in early and(More)
Simple and full-length array LDPC codes (SFA-LDPC codes) is a class of LDPC codes which are algebraically constructed from a family of array codes. The minimum weight of SFA-LDPC codes has been investigated in literatures, but exact minimum weight of the code is not known except for some small parameters. In this paper it is shown that the class of SFA-LDPC(More)
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted. During pathological neovascularization, both the absolute and relative expression levels for VEGF164 increased to a(More)
PURPOSE The interaction of advanced glycation end products (AGEs) with their receptors is hypothesized to be involved in the development of diabetic retinopathy. In the present study, the role of an AGE receptor, RAGE, was investigated in the development of diabetic retinopathy in vivo. METHODS C57/BJ6 and RAGE-transgenic mice that carried human RAGE(More)
It is a well-known theorem by Chomsky and Schützenberger (1963) that every context-free language can be represented as a homomorphic image of the intersection of a Dyck language and a regular language. This paper gives a Chomsky-Schützenberger-type characterization for multiple context-free languages, which are a natural extension of context-free languages,(More)
A term rewriting system which effectively preserves recognizability (EPR-TRS) has good mathematical properties. In this paper, a new subclass of TRSs, layered transducing TRSs (LT-TRSs) is defined and its recognizability preserving property is discussed. The class of LT-TRSs contains some EPRTRSs, e.g., {f(x) → f(g(x))} which do not belong to any of the(More)
PURPOSE The corneal endothelium is a target of the aging process. This study was undertaken to reveal the relationship between corneal endothelial cell (CEC) death and the accumulation of advanced glycation end products (AGEs), by investigating the possible mechanism of accumulation of AGE in CECs and its effects on CEC death. METHODS First, the in vivo(More)
PURPOSE Vascular endothelial growth factor (VEGF) induces angiogenesis and vascular permeability and is thought to be operative in several ocular vascular diseases. The VEGF isoforms are highly conserved among species; however, little is known about their differential biological functions in adult tissue. In the current study, the inflammatory potential of(More)
PURPOSE A critical event in the pathogenesis of diabetic retinopathy is the inappropriate adherence of leukocytes to the retinal capillaries. Advanced glycation end-products (AGEs) are known to play a role in chronic inflammatory processes, and the authors postulated that these adducts may play a role in promoting pathogenic increases in proinflammatory(More)