Yuichi Hirayama

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AIM Regulatory T cells (Tregs) maintain immunological tolerance and suppress autoreactive immune responses. We evaluated the intrahepatic status of Tregs in patients with autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), chronic hepatitis C (CH-C), or chronic hepatitis B (CH-B). METHODS We analyzed 85 patients (20 AIH, 22 PBC, 27 CH-C, and 16(More)
Esophageal squamous cell carcinoma (ESCC) exhibits abnormalities in epidermal growth factor receptor (EGFR) gene. To identify a prognostic marker, the overexpression of EGFR protein, mutations in EGFR and p53 mutations were analyzed in pretreatment biopsy specimens removed from T3-4 and/or M1 LYM ESCC patients who received chemoradiotherapy. A silent(More)
Accumulation of activated lymphocytes in the liver has been reported in patients with autoimmune liver diseases; the activity of these cells may be related to the disease immunopathogenesis. Although immuno-inhibitory molecules on lymphocytes are thought to play an important role in immunomodulation, there are only a few reports on the status of these(More)
Atmospheric pollution affects the health through complex mechanisms and to varying degrees. However, even by secondary usage of retrospective HIS and "AEROS" data, screening can be performed for specific ICD10 diseases caused by environmental factors. Our screening method showed good agreement with doctors' common knowledge on the relationship between(More)
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