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Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination
Significance T-cell activation requires the translation of antigen binding to the T-cell receptor (TCR) into intracellular signaling. However, how antigen recognition and signal transduction areExpand
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Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells
Phosphorylation of the T cell receptor (TCR) by the kinase Lck is the first detectable signaling event upon antigen engagement. The distribution of Lck within the plasma membrane, its conformationalExpand
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A FRET sensor enables quantitative measurements of membrane charges in live cells
Membrane charge has a critical role in protein trafficking and signaling. However, quantification of the effective electrostatic potential of cellular membranes has remained challenging. We developedExpand
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An intermolecular FRET sensor detects the dynamics of T cell receptor clustering
Clustering of the T-cell receptor (TCR) is thought to initiate downstream signalling. However, the detection of protein clustering with high spatial and temporal resolution remains challenging. HereExpand
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Discreet and distinct clustering of five model membrane proteins revealed by single molecule localization microscopy
Abstract Compartmentalization is a functionally important property of the plasma membrane, yet the underlying principles that organize membrane proteins into distinct domains are not well understood.Expand
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Addendum: Editorial Expression of Concern: DNA-guided genome editing using the Natronobacterium gregoryi Argonaute
The editors of Nature Biotechnology are issuing an editorial expression of concern regarding this article to alert our readers to concerns regarding the reproducibility of the original results. AtExpand
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Effect of various alkaline metal ions on electrochemical behavior of lead electrode in sulfuric acid solution
Abstract The effect of various alkaline metal ions on electrochemical behavior of lead electrode in sulfuric acid solution has been investigated. It was found that “the specific anodic oxidationExpand
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Thermal Dehydration of Lithium Sulfate Monohydrate Revisited with Universal Kinetic Description over Different Temperatures and Atmospheric Water Vapor Pressures
This study aims to universally describe the kinetic features of the thermal dehydration of lithium sulfate monohydrate across different temperatures (T) and atmospheric water vapor pressures (p(H2O...
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Corrigendum: A FRET sensor enables quantitative measurements of membrane charges in live cells.
Corrigendum: A FRET sensor enables quantitative measurements of membrane charges in live cells
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Kinetic analysis of the multistep thermal decomposition of Maya Blue-type pigments to evaluate thermal stability
This study aimed to evaluate the practical usefulness of kinetic deconvolution analysis (kDa) as a means to obtain the kinetic information on specific reaction steps that characterize the thermalExpand