Yuhua J. Du

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We developed highly predictive classification models for human liver microsomal (HLM) stability using the apparent intrinsic clearance (CL(int, app)) as the end point. HLM stability has been shown to be an important factor related to the metabolic clearance of a compound. Robust in silico models that predict metabolic clearance are very useful in early drug(More)
Fragment Based Drug Discovery (FBDD) continues to advance as an efficient and alternative screening paradigm for the identification and optimization of novel chemical matter. To enable FBDD across a wide range of pharmaceutical targets, a fragment screening library is required to be chemically diverse and synthetically expandable to enable critical decision(More)
Pulsars have been recognized as normal neutron stars, but sometimes argued as quark stars. Sub-millisecond pulsars, if detected, would play an essential and important role in distinguishing quark stars from neutron stars. We focus on the formation of such sub-millisecond pulsars in this paper. A new approach to form a sub-millisecond pulsar (quark star) via(More)
Pulsars have been recognized as normal neutron stars or quark stars. Sub-millisecond pulsars, if detected, would play an essential and important role in distinguishing quark stars from neutron stars. A key question is how sub-millisecond pulsars could be formed. Both sub-Keplerian (for neutron and quark stars) and super-Keplerian cases (only for quark(More)
The subdivisions of the sacral intermediolateral nucleus (IML) of the cat have been studied by using a double-labeling technique of retrograde Fluoro-gold (FG) and wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) tracing. The parasympathetic preganglionic neurons (PGNs) that were labeled by the FG injected into the pelvic nerve formed a(More)
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