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Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 (TH2) lymphocytes and their cytokines have an important role in allergic asthma. Interleukin (IL)-9, a member of the TH2 cytokine family, has recently been(More)
Cryptotanshinone (CPT), a diterpene quinone isolated from Salvia miltiorrhiza, is recently reported to have obvious anticancer activities against diverse cancer cells. However, the effect and regulatory mechanism of CPT remain unclear in human chronic myeloid leukemia (CML) cells. In this study, we investigated the antiproliferative activity of CPT on the(More)
This research innovatively extends optimal emergency facility location models to the interior space of multistory buildings with an integrated spatial-temporal framework. We present the case of deployed emergency medical devices known as automated external defibrillators (AEDs), which serve to treat sudden cardiac arrest on-site within the first few(More)
Current strategies for the production of therapeutic mAbs include the use of mammalian cell systems to recombinantly produce Abs derived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage libraries. Generation of hybridomas secreting human mAbs has been previously reported; however, this approach has not been fully exploited for(More)
Over-expression of endosialin/CD248 (herein referred to as CD248) has been associated with increased tumor microvasculature in various tissue origins which makes it an attractive anti-angiogenic target. In an effort to target CD248, we have generated a human CD248 knock-in mouse line and MORAb-004, the humanized version of the mouse anti-human CD248(More)
High spatial resolution (HSR) imagery and high density LiDAR data provide complementary horizontal and vertical information. Therefore, many studies have focused on fusing the two for mapping geographic features. It has been demonstrated that the synergetic use of LiDAR and HSR imagery greatly improves classification accuracy. This is especially true with(More)
The objective of this study is to develop new algorithms for automated urban forest inventory at the individual tree level using LiDAR point cloud data. LiDAR data contain three-dimensional structure information that can be used to estimate tree height, base height, crown depth, and crown diameter. This allows precision urban forest inventory down to(More)
Modeling plays an important role in bioprocess development for design and scale-up. Predictive models can also be used in biopharmaceutical manufacturing to assist decision-making either to maintain process consistency or to identify optimal operating conditions. To predict the whole bioprocess performance, the strong interactions present in a processing(More)
BACKGROUND Staphylococcal enterotoxins are considered potential biowarfare agents that can be spread through ingestion or inhalation. Staphylococcal enterotoxin B (SEB) is a widely studied superantigen that can directly stimulate T-cells to release a massive amount of proinflammatory cytokines by bridging the MHC II molecules on an antigen presenting cell(More)