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Virtual Screening and Molecular Dynamics Study of Potential Negative Allosteric Modulators of mGluR1 from Chinese Herbs
TLDR
The applicability of molecular simulation technologies for discovering potential natural mGluR1 NAMs from Chinese herbs is indicated and thesinine-4ʹ-O-β-d-glucoside, nigrolineaxanthone-P and nodakenin might exhibit negative allosteric moderating effects on mGLUR1.
Role of Breast Milk in a Mouse Model of Maternal Transmission of Asthma Susceptibility1
TLDR
Breast milk is sufficient, but not necessary, to mediate allergen-independent maternal transmission of asthma risk to offspring, and multiplex assays for cytokines in breast milk were negative.
Terahertz time-domain spectroscopy combined with support vector machines and partial least squares-discriminant analysis applied for the diagnosis of cervical carcinoma
Coupled with terahertz time-domain spectroscopy (THz-TDS) technology, the feasibility for the diagnosis of cervical carcinoma using support vector machines (SVM) and partial least
Immunostimulatory CpG Oligonucleotides Abrogate Allergic Susceptibility in a Murine Model of Maternal Asthma Transmission1
TLDR
The potential for immunomodulatory therapy with CpG in early life to reduce susceptibility to asthma is supported, and treatment just before OVA aerosol challenge also prevented allergic responses.
3D-QSAR study of hallucinogenic phenylalkylamines by using CoMFA approach
TLDR
The three-dimensional quantitative structure–activity relationship (3D-QSAR) has been studied on 90 hallucinogenic phenylalkylamines by the comparative molecular field analysis (CoMFA) and the model showed good predictive ability in the external test and coefficient contour maps suggested that both steric and electrostatic interactions play an important role.
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