Yuh-Lin Wang

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Rapid and accurate diagnosis for pathogens and their antibiotic susceptibility is critical for controlling bacterial infections. Conventional methods for determining bacterium's sensitivity to antibiotic depend mostly on measuring the change of microbial proliferation in response to the drug. Such "biological assay" inevitably takes time, ranging from days(More)
—Bacterial meningitis is still a life-threatening disease , and early diagnosis of pathogen can be crucial to improving survival rate. Using the surface-enhanced Raman scattering (SERS) platform developed by our group, the pathogens can be differentiated on the basis of their SERS spectra which are believed to related to their surface chemical components.(More)
A multiscale approach for peak representation and identification is proposed in the context of surface-enhanced Raman spectroscopy (SERS). The SERS spectrum is naturally composed of peaks with different preferred scales, and some tiny but reproducible peaks can be important distinguishing factors. However, if only a single scale is employed, there is a(More)
It has been shown that an anisotropic metamaterial made of nanowire array can realize negative refraction of light even without a negative phase index of refraction. Such non-resonant bulk material can be fabricated by bottom-up electrochemical method. Using this material, we were able to achieve lensing action with micron-thick slab and demonstrate imaging(More)
—We propose a pathogen-classification system using the Surface-Enhanced Raman Scattering (SERS) platform. The system differentiates the pathogens based on their SERS spectra , which are believed to be related to the surface chemical components. The specialty of the system is to not only consider the usual classification accuracy, but also pay attention to(More)
To exploit Rashba effect in a 2D electron gas on silicon surface for spin transport, it is necessary to have surface reconstruction with spin-split metallic surface-state bands. However, metals with strong spin-orbit coupling (e.g., Bi, Tl, Sb, Pt) induce reconstructions on silicon with almost exclusively spin-split insulating bands. We propose a strategy(More)
In this research, graphene nanosheets were functionalized with cationic poly (diallyldimethylammonium chloride) (PDDA) and citrate-capped gold nanoparticles (AuNPs) for surface-enhanced Raman scattering (SERS) bio-detection application. AuNPs were synthesized by the traditional citrate thermal reduction method and then adsorbed onto graphene-PDDA nanohybrid(More)
Rapid bacterial antibiotic susceptibility test (AST) and minimum inhibitory concentration (MIC) measurement are important to help reduce the widespread misuse of antibiotics and alleviate the growing drug-resistance problem. We discovered that, when a susceptible strain of Staphylococcus aureus or Escherichia coli is exposed to an antibiotic, the intensity(More)
In this study, multifunctional hybrid nanoparticles composed of iron platinum (FePt), silica (SiO2), and gold nanoparticles (AuNPs) had been developed for surface-enhanced Raman scattering (SERS) application. Core-shell structure of SiO2 and FePt nanoparticles (FePt@SiO2) was fabricated through sol-gel process and then immobilized gold nanoparticles onto(More)
Indefinite optical properties, which are typically characterized by hyperbolic dispersion relations, have not been observed in naturally occurring materials, but can be realized through a metamaterial approach. We present here the design, fabrication and characterization of nanowire metamaterials with indefinite permittivity, in which all-angle negative(More)