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In this paper, we study the boundary behaviors of compact manifolds with nonnegative scalar curvature and nonempty boundary. Using a general version of Positive Mass Theorem of Schoen-Yau and Witten, we prove the following theorem: For any compact manifold with boundary and nonneg-ative scalar curvature, if it is spin and its boundary can be isometrically(More)
Melanin-concentrating hormone (MCH) is a cyclic peptide that mediates its effects by the activation of two G-protein-coupled seven transmembrane receptors (MCHR1 and MCHR2) in humans. In contrast to its primary role in regulating skin color in fish, MCH has evolved in mammals to regulate dynamic physiological functions, from food intake and energy(More)
In the first part of this work, the Poisson equation on complete noncom-pact manifolds with nonnegative Ricci curvature is studied. Sufficient and necessary conditions for the existence of solutions with certain growth rates are obtained. Sharp estimates on the solutions are also derived. In the second part, these results are applied to the study of(More)
Overnutrition and genetics both contribute separately to pancreatic β-cell dysfunction, but how these factors interact is unclear. This study was aimed at determining whether microRNAs (miRNAs) provide a link between these factors. In this study, miRNA-24 (miR-24) was highly expressed in pancreatic β-cells and further upregulated in islets from genetic(More)
Runx2, an essential transactivator for osteoblast differentiation, is tightly regulated at both the transcriptional and posttranslational levels. In this paper, we report that CHIP (C terminus of Hsc70-interacting protein)/STUB1 regulates Runx2 protein stability via a ubiquitination-degradation mechanism. CHIP interacts with Runx2 in vitro and in vivo. In(More)
Acyl-coenzyme A:monoacylglycerol acyltransferase 3 (MGAT3) is a member of the MGAT family of enzymes that catalyze the synthesis of diacylglycerol (DAG) from monoacylglycerol (MAG), a committed step in dietary fat absorption. Although named after the initial identification of its MGAT activity, MGAT3 shares higher sequence homology with acyl-coenzyme(More)
In this paper, we will study the limiting behavior of the Brown-York mass of the coordinate spheres in an asymptoti-cally flat manifold. Limiting behaviors of volumes of regions related to coordinate spheres are also obtained, including a discussion on the isoperimetric mass introduced by Huisken [13]. We will also study expansions of the Brown-York mass(More)