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Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells
The data suggest that Hes5 expression is serially activated first by Gcms and later by the canonical Notch pathway, and this activation is indispensable for the generation of neural stem cells.
Regional Cellular Environment Shapes Phenotypic Variations of Hippocampal and Neocortical Chandelier Cells
- Yugo Ishino, Michael J. Yetman, Serena M. Sossi, André Steinecke, Yasufumi Hayano, H. Taniguchi
- BiologyThe Journal of Neuroscience
- 11 October 2017
The results provide evidence of striking differences in axonal/synaptic organization and calretinin expression between hippocampal chandelier cells (ChCs) and neocortical ChCs and reveal that local cellular environment in distinct cortical regions regulates these terminal phenotypes.
Neocortical Chandelier Cells Developmentally Shape Axonal Arbors through Reorganization but Establish Subcellular Synapse Specificity without Refinement
Visual Abstract Diverse types of cortical interneurons (INs) mediate various kinds of inhibitory control mechanisms to balance and shape network activity. Distinct IN subtypes develop uniquely…
The Lewis X-related α1,3-Fucosyltransferase, Fut10, Is Required for the Maintenance of Stem Cell Populations*
The data suggest that Fut10 is involved in a unique α1,3-fucosyltransferase activity with stringent substrate specificity, and that this activity is required to maintain stem cells in an undifferentiated state.
Sulfatase 2 Modulates Fate Change from Motor Neurons to Oligodendrocyte Precursor Cells through Coordinated Regulation of Shh Signaling with Sulfatase 1
There is a threshold for sulfatase activity required to induce the MN-to-OPC fate change, and Shh signaling requires the coordinated activity of Sulf1 and Sulf2 in order to reach that threshold in the mouse ventral spinal cord.
Neoblast‐enriched fraction rescues eye formation in eye‐defective planarian ‘menashi’Dugesia ryukyuensis
- K. Kobayashi, Toshiyuki Hashiguchi, Taiichiro Ichikawa, Yugo Ishino, M. Hoshi, M. Matsumoto
- BiologyDevelopment, growth & differentiation
- 1 October 2008
A genetic mutant planarian, menashi, an eye‐defective mutant that lacks the pigmented area in the eyes, was established, and it is suggested that the neoblast‐rich fraction contains cells that can proliferate and differentiate.
The Dorsoventral Boundary of the Germinal Zone is a Specialized Niche for the Generation of Cortical Oligodendrocytes during a Restricted Temporal Window.
The results suggest that neural stem cells at this boundary are uniquely specialized to produce myelin-forming OLs in the cortex, while neural precursor cells present in the dorsoventral boundary VZ/SVZ produce a significant amount of OL's in the adult cortex.
Keratan Sulfate Regulates the Switch from Motor Neuron to Oligodendrocyte Generation During Development of the Mouse Spinal Cord
Results indicate that KS is important for the late phase Shh signaling and contributes to motor neuron to OPC generation switch.
Coactivator‐associated arginine methyltransferase 1 controls oligodendrocyte differentiation in the corpus callosum during early brain development
- Yugo Ishino, Shoko Shimizu, M. Tohyama, S. Miyata
- Biology, ChemistryDevelopmental neurobiology
- 26 February 2022
It is proposed that Carm1 is an essential molecule for the development of OPCs and OLs during brain development through its regulation of cell proliferation and the induction of the clustering of Caspr, a node of Ranvier structural molecule.
Antidepressive Effects of Kamishoyosan through 5-HT1AReceptor and PKA-CREB-BDNF Signaling in the Hippocampus in Postmenopausal Depression-Model Mice
- Shoko Shimizu, Yugo Ishino, Takashi Takeda, M. Tohyama, S. Miyata
- Biology, PsychologyEvidence-based complementary and alternative…
- 3 November 2019
It is suggested that Kamishoyosan improves neuropsychiatric symptoms through 5-HT1AR and PKA-CREB-BDNF signaling in the hippocampus in postmenopausal women.