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Ropivacaine impairs mitochondrial biogenesis by reducing PGC-1α.
TLDR
Supporting evidence is provided that mitochondrial impairment is a key event in ropivacaine-mediated neurotoxicity, and the reduction of PGC-1α and its downstream signals are likely the molecular mechanism behind its cellular toxicity. Expand
Influence of Dexmedetomidine on Toxicity of Intrathecal Ketamine on Neonatal Rat Spinal Function
TLDR
Co-administration of dexmedetomidine and ketamine suggests that the former reduced apoptosis counts, altered glial responses, increased mechanical withdrawal threshold and improved gait, and protects against intrathecal ketamine-induced spinal toxicity in neonatal rats. Expand