Yueting Zhang

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2-Aminopyrimidin-4(1H)-one was proposed as the novel bioisostere of urea. Bioisosteric replacement of the reported urea series of the CXCR2 antagonists with 2-aminopyrimidin-4(1H)-ones led to the discovery of the novel and potent CXCR2 antagonist 3e. 2-Aminopyrimidin-4(1H)-one derivative 3e demonstrated a good developability profile (reasonable solubility(More)
In synthetic aperture radar (SAR) imagery, relating to maritime surveillance studies, the ship has always been the main focus of study. In this letter, a method of ship classification in SAR images is proposed to enhance classification accuracy. In the proposed method, to fully exploit the distinguishing characters of the ship targets, both topology and(More)
This paper designs an embedded 3G gateway that closely combines sensor technology, embedded technology and 3G technology. The gateway based on ARM9 processor takes embedded Linux 2.6 as the real time operation system. In this design, data from short-range wireless sensor network will be collected and aggregated after sensing and then sent to the control(More)
Glioblastoma is the most aggressive brain tumor, and its prognosis remains poor. Therefore, novel therapeutic strategies are needed for glioma therapy. Polyphyllin I (PPI), a bioactive constituent extracted from Paris polyphylla, was reported to have anti-tumor activity. However, the detailed mechanism for this activity remains unclear. Here, we(More)
Structure-activity relationship exploration of the historical biarylurea series led to the identification of novel CNS penetrant CXCR2 antagonists with nanomolar potency, favorable PK profile, and good developability potentials. More importantly, the key compound 22 showed efficacy in a cuprizone-induced demyelination model with twice daily oral(More)