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Several polymorphisms in the APOA5 gene have been associated with increased plasma triglyceride (TG) concentrations. However, associations between APOA5 and lipoprotein subclasses, remnant-like particles (RLPs), and cardiovascular disease (CVD) risk have been less explored. We investigated associations of five APOA5 single-nucleotide polymorphisms (SNPs;(More)
BACKGROUND Citrasate®, citric acid dialysate (CD), contains 2.4 mEq of citric acid (citrate), instead of acetic acid (acetate) as in standard bicarbonate dialysate. Previous studies suggest CD may improve dialysis adequacy and decrease heparin requirements, presumably due to nonsystemic anticoagulant effects in the dialyzer. METHODS We prospectively(More)
OBJECTIVES Chronic insomnia and depression are often associated. Measuring the impact on quality of life associated with changes in sleep in co-treatment of insomnia and depression requires a valid and reliable patient reported outcome (PRO) instrument. This study aimed to assess the validity of the Sleep Impact Scale (SIS), a sleep-specific PRO instrument,(More)
High density lipoprotein cholesterol (HDL-C) is inversely associated with coronary heart disease and has a genetic component; however, linkage to HDL-C is not conclusive. Subfractions of HDL, such as HDL(3)-C, may be better phenotypes for linkage studies. Using HDL(3)-C levels measured on 907 Framingham Heart Study subjects from 330 families around 1987, we(More)
We consider properties of second-order operatorsH = − ∑d i,j=1 ∂i cij ∂j on R with bounded real symmetric measurable coefficients. We assume that C = (cij) ≥ 0 almost everywhere, but allow for the possibility that C is singular. We associate with H a canonical self-adjoint viscosity operator H0 and examine properties of the viscosity semigroup S generated(More)
We consider partial differential operators H = − div(C∇) in divergence form on R with a positive-semidefinite, symmetric, matrix C of real L∞-coefficients. First, we prove that one can define H as a selfadjoint operator on L2(R ) such that the corresponding semigroup extends as a positive, contraction semigroup to all the Lp-spaces. Secondly, we establish(More)
Little is known about the prevalence of drug-resistant mutations in HIV-1-positive individuals in Suzhou, China. To elucidate the transmitted drug resistance (TDR) and acquired drug resistance mutation (ADR) profiles, we collected blood specimens from 127 drug-naïve and 117 first-line drug-treated HIV-1-infected individuals sampled from 2014 to 2016 in(More)
We apply the discrete version of Calderón’s reproducing formula and Littlewood–Paley theory with weights to establish the H w → H w (0 < p < ∞) and H w → Lw (0 < p ≤ 1) boundedness for singular integral operators and derive some explicit bounds for the operator norms of singular integrals acting on these weighted Hardy spaces when we only assume w ∈ A∞. The(More)
BACKGROUND Apolipoprotein A5 gene (APOA5) variation is associated with plasma triglycerides (TGs). However, little is known about whether dietary fat modulates this association. METHODS AND RESULTS We investigated the interaction between APOA5 gene variation and dietary fat in determining plasma fasting TGs, remnant-like particle (RLP) concentrations, and(More)