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BACKGROUND Frailty and hyperhomocysteinemia are common in the older population. The researchers' objectives were to determine whether elevated homocysteine (tHcy) is associated with frailty and mortality. METHODS The researchers conducted a prospective cohort study. tHcy was measured by immunoassay in 4,248 community-dwelling men aged 70-88 years. Frailty(More)
BACKGROUND Minimal trauma hip fractures are prevalent in Australia. The incidence rate and trend of hip fractures in Indigenous Western Australians have not been formally reported. AIMS To evaluate incidence rates and trend of minimal trauma hip fractures in Indigenous and other Western Australians aged 40 years and over in 1999-2009 METHODS: Hip fracture(More)
CONTEXT AND OBJECTIVE Prostate, colorectal and lung cancers are common in men. In this study, we aimed to determine whether vitamin D status is associated with the incidence of these cancers in older men. DESIGN Prospective cohort study. SETTING AND PARTICIPANTS 4208 older men aged 70-88 years in Perth, Western Australia. MAIN OUTCOME MEASURES Plasma(More)
OBJECTIVE This study was conducted to determine whether plasma total homocysteine (tHcy) and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism are associated with abdominal aortic aneurysm (AAA) and aortic diameter. METHODS This was a cross-sectional study set in Western Australia of 4248 community-dwelling men aged 70 to 88 years.(More)
CONTEXT AND OBJECTIVE Hypovitaminosis D and frailty are common in the older population. We aimed to determine whether 25-hydroxyvitamin D [25(OH)D] concentrations are associated with frailty and mortality. DESIGN We conducted a prospective cohort study. SETTING AND PARTICIPANTS Participants included 4203 older men aged 70-88 years in Perth, Western(More)
OBJECTIVE This study aims to investigate the association between plasma 25-hydroxyvitamin D (25(OH)D) concentrations with the presence of abdominal aortic aneurysm (AAA) and aortic diameter. DESIGN An observational study of 4233 community-dwelling men aged 70-88 years, who participated in a randomised controlled trial of screening for AAA. METHODS(More)
OBJECTIVES To determine the relationship between high total homocysteine (tHcy) and self-perceived physical health, by investigating the associations between tHcy, the methylenetetrahydrofolate reductase (MTHFR) 677T polymorphism and physical health-related quality of life (HRQOL). STUDY DESIGN We conducted a cross-sectional study using a cohort of 4248(More)
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