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The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

• Zhuo-shen Zhao, Jet Phey Lim, Yuen-Wai Ng, Louis Lim, Ed Manser
• Molecular cell
• 2005

Previously, we showed PAK-PIX-GIT targets and regulates focal adhesions; here, we uncover a different function for the complex at the centrosome. Active PAK1 is particularly evident in mitosis and… (More)

GIT1 activates p21-activated kinase through a mechanism independent of p21 binding.

• Tsui-Han Loo, Yuen-Wai Ng, Louis Lim, Ed Manser
• Molecular and cellular biology
• 2004

p21-activated kinases (PAKs) associate with a guanine nucleotide exchange factor, Pak-interacting exchange factor (PIX), which in turn binds the paxillin-associated adaptor GIT1 that targets the… (More)

Group I and II mammalian PAKs have different modes of activation by Cdc42.

• Yohendran Baskaran, Yuen-Wai Ng, Widyawilis Selamat, Felicia Tay Pei Ling, Ed Manser
• EMBO reports
• 2012

p21-activated kinases (PAKs) are Cdc42 effectors found in metazoans, fungi and protozoa. They are subdivided into PAK1-like (group I) or PAK4-like (group II) kinases. Human PAK4 is widely expressed… (More)

Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation.

• Jing-Ming Dong, Lei-Shong Lau, Yuen-Wai Ng, Louis Lim, Ed Manser
• The Biochemical journal
• 2009

Paxillin, a major focal-adhesion complex component belongs to the subfamily of LIM domain proteins and participates in cell adhesion-mediated signal transduction. It is implicated in cell-motility… (More)

A robust protocol to map binding sites of the 14-3-3 interactome: Cdc25C requires phosphorylation of both S216 and S263 to bind 14-3-3.

• Perry M. Chan, Yuen-Wai Ng, Ed Manser
• Molecular & cellular proteomics : MCP
• 2011

Modern proteomic techniques have identified hundreds of proteins that bind 14-3-3s, the most widespread eukaryotic phosphoserine/threonine sensors, but accurate prediction of the target phospho-sites… (More)

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination

• María Isabel Neiva Acosta, S. Urbach, +7 authors Emmanuel Lemichez
• Scientific Reports
• 2018

The regulation of Rac1 by HACE1-mediated ubiquitination and proteasomal degradation is emerging as an essential element in the maintenance of cell homeostasis. However, how the E3 ubiquitin ligase… (More)

Why an A-loop phospho-mimetic fails to activate PAK1: understanding an inaccessible kinase state by molecular dynamics simulations.

• Yuen-Wai Ng, Devanathan Raghunathan, +5 authors Ed Manser
• Structure
• 2010

Crystal structures of inactive PAK1(K299R) and the activation (A)-loop phospho-mimetic PAK1(T423E) have suggested that the kinase domain is in an active state regardless of activation loop status.… (More)

IImammalian PAKs have differentmodes of activation by Cdc 42

• Yohendran Baskaran, Yuen-Wai Ng, Widyawilis Selamat, Felicia Tay Pei Ling, Ed Manser
• 2013

p21-activated kinases (PAKs) are Cdc42 effectors found in metazoans, fungi and protozoa. They are subdivided into PAK1like (group I) or PAK4-like (group II) kinases. Human PAK4 is widely expressed… (More)

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