Yuen-Man Chan

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Transection of the optic nerve initiates massive death of retinal ganglion cells (RGCs). Interestingly, despite the severity of the injury, RGC loss was not observed until several days after axotomy. The mechanisms responsible for this initial lack of RGC death remained unknown. In the current study, immunohistochemical analysis revealed that caspases-3 and(More)
The present study examined whether a peripheral nerve (PN) graft can rescue developing motoneurons from degeneration and determined when immature motoneurons begin to express a regenerative capacity. Transplantation of a PN graft was unable to rescue motoneurons from degeneration if spinal root avulsion was performed in animals younger than P14. However,(More)
We examined whether (1) a pan-caspase inhibitor, Boc-D-FMK, exerts long-term neuroprotective effects on spinal motoneurons (MNs) after root avulsion in neonatal rats and (2) whether the rescued spinal MNs regenerate their axons into a peripheral nerve (PN) graft and reinnervate a previously denervated target muscle. Eight weeks after root avulsion, 67% of(More)
Introduction: We examined the mode of spinal motoneuron (MN) cell death after peripheral nerve injury in neonatal rats. Method: Following root avulsion at C7 spinal segment in neonatal day 1 rats, either PBS or caspase inhibitors was applied onto the lesioned area. The postoperative period was 1, 2, 4, 6, 18, 24 and 48 hours. The time course of apoptosis(More)
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